Designing a deep brain stimulator to suppress pathological neuronal synchrony

Some of neuropathologies are believed to be related to abnormal synchronization of neurons. In the line of therapy, designing effective deep brain stimulators to suppress the pathological synchrony among neuronal ensembles is a challenge of high clinical relevance. The stimulation should be able to...

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Bibliographic Details
Published in:Neural networks 2015-03, Vol.63, p.282-292
Main Authors: Montaseri, Ghazal, Yazdanpanah, Mohammad Javad, Bahrami, Fariba
Format: Article
Language:English
Subjects:
Adaptive structure
Brain
Brain - physiology
Brain Waves
Computer simulation
Dealing
Deep Brain Stimulation - instrumentation
Deep Brain Stimulation - methods
Desynchronizing stimulation
Hindmarsh–Rose neural networks
Humans
Models, Neurological
Neural networks
Neurons
Stimulation
Stimulators
Synchronization
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Summary:Some of neuropathologies are believed to be related to abnormal synchronization of neurons. In the line of therapy, designing effective deep brain stimulators to suppress the pathological synchrony among neuronal ensembles is a challenge of high clinical relevance. The stimulation should be able to disrupt the synchrony in the presence of latencies due to imperfect knowledge about parameters of a neuronal ensemble and stimulation impacts on the ensemble. We propose an adaptive desynchronizing deep brain stimulator capable of dealing with these uncertainties. We analyze the collective behavior of the stimulated neuronal ensemble and show that, using the designed stimulator, the resulting asynchronous state is stable. Simulation results reveal the efficiency of the proposed technique.
ISSN:0893-6080
1879-2782
DOI:10.1016/j.neunet.2014.12.008