Difference in the toxicity mechanism between ion and nanoparticle forms of silver in the mouse lung and in macrophages

Highlights • Toxicity of AgNPs was compared to that of Ag ions both in vitro and in vivo. • Ag ions are more cytotoxic and induced metallothioneins in macrophages. • AgNPs gradually dissolved and caused mild inflammation in the lung.

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2015-02, Vol.328, p.84-92
Main Authors: Arai, Yuta, Miyayama, Takamitsu, Hirano, Seishiro
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biological Transport
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Cell Line
Cell Survival - drug effects
Dose-Response Relationship, Drug
Emergency
In vitro testing
Inflammation Mediators - metabolism
Inhalation Exposure - adverse effects
Interleukin-1beta - metabolism
Liver - metabolism
Lung
Lung - drug effects
Lung - immunology
Lung - metabolism
Lung - pathology
Lungs
Lysosome
Lysosomes
Lysosomes - drug effects
Lysosomes - metabolism
Macrophages
Macrophages - drug effects
Macrophages - immunology
Macrophages - metabolism
Macrophages - pathology
Male
Metal Nanoparticles - toxicity
Metallothionein
Metallothionein - metabolism
Mice, Inbred ICR
Molecular Weight
Neutrophil Infiltration - drug effects
Neutrophils - drug effects
Neutrophils - immunology
Neutrophils - metabolism
Particle Size
Proteins
Silver
Silver ion
Silver nanoparticle
Silver Nitrate - metabolism
Silver Nitrate - toxicity
Stimulation
Time Factors
Toxicity
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Description
Summary:Highlights • Toxicity of AgNPs was compared to that of Ag ions both in vitro and in vivo. • Ag ions are more cytotoxic and induced metallothioneins in macrophages. • AgNPs gradually dissolved and caused mild inflammation in the lung.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2014.12.014