Intermolecular Dearomatization Reaction of Pyrroles Promoted by Silica Gel

An efficient synthesis of polysubstituted 2H‐pyrrole derivatives via a silica gel‐promoted intermolecular dearomative Michael addition of pyrroles with α,β‐unsaturated ketones has been developed. This transformation features environmentally benign promoter, high efficiency, wide substrate scope and...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2015-03, Vol.357 (5), p.912-916
Main Authors: Zhou, Yong, Zhuo, Chun-Xiang, Gu, Qing, You, Shu-Li
Format: Article
Language:English
Subjects:
alkylation
Catalysis
dearomatization
Derivatives
Ketones
Michael addition
Pyrroles
Silica gel
Silicon dioxide
Synthesis
Transformations
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Summary:An efficient synthesis of polysubstituted 2H‐pyrrole derivatives via a silica gel‐promoted intermolecular dearomative Michael addition of pyrroles with α,β‐unsaturated ketones has been developed. This transformation features environmentally benign promoter, high efficiency, wide substrate scope and mild reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201401150