Silver nanoparticles/multi walled carbon nanotubes nanocomposite modified electrode: Voltammetric determination of clonazepam

• Published in: Electrochimica acta 2014-02, Vol.118, p.10-17
• Main Authors: Habibi, Biuck, Jahanbakhshi, Mojtaba
• Format: Article
• Language: English
• Subjects: Clonazepam; Electrodes; Electroreduction; Multi wall carbon nanotubes; Multi walled carbon nanotubes; Nanocomposite; Nanoparticles; Nanostructure; Reduction; Reproducibility; Silver; Silver nanoparticles; Voltammetry
• ISSN: 0013-4686; 1873-3859
• DOI: 10.1016/j.electacta.2013.11.169

Schematic representation of clonazepam (CZP) electroreduction on the AgNPs/MWCNTs/GCE. •Electrocatalytic reduction of clonazepam on the AgNPs/MWCNTs/GCE.•Voltammetric determination of clonazepam on the AgNPs/MWCNTs/GCE for the first time.•The method has wide linear range, low detection limit and high selectivity.•DPV determination of clonazepam in some real sample. In the present study, a new, simple and highly sensitive electrochemical method is developed for the determination of clonazepam (CZP) based on a silver nanoparticles/multi walled carbon nanotubes nanocomposite modified glassy carbon electrode (AgNPs/MWCNTs/GCE). Cyclic voltammetry and differential pulse voltammetry (DPV) methods were used for the electrochemical studies and measurements. The obtained results show that the AgNPs/MWCNTs/GCE exhibits high electrocatalytic activity toward the reduction of CZP. During the electrochemical reduction of CZP, an irreversible cathodic peak appears at about -0.61V vs. silver/silver chloride electrode. The DPV measurements confirmed that the reduction peak currents increased linearly with CZP concentration in the range of 5.0×10−8 - 2.5×10−6M with a detection limit of 6.0×10−9M. The stability, reproducibility and repeatability of the nanocomposite modified electrode were checked and the obtained relative standard deviations showed that the AgNPs/MWCNTs/GCE had excellent stability, reproducibility and repeatability. Finally, the nanocomposite modified electrode was effectively applied for the determination of CZP in some real samples without any interference.