Novel carboxylated PEG-coating on magnetite nanoparticles designed for biomedical applications

Fabrication of PEG coating on magnetite nanoparticles (MNPs) is one of the most favoured ways to ensure biocompatibility. Surface modification of magnetite by an own-prepared comb-like PEG-copolymer (PEGA-AA) was compared with two commercially available ones (carboxy-PEG (PEG-C) and phosphate-PEG (P...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetism and magnetic materials 2015-04, Vol.380, p.132-139
Main Authors: Illés, Erzsébet, Tombácz, Etelka, Szekeres, Márta, Tóth, Ildikó Y., Szabó, Ákos, Iván, Béla
Format: Article
Language:English
Subjects:
Biomedical application
Carbon
Coating
Colloid stability
Dispersing
Electrophoresis
Light scattering
Magnetite
Magnetite nanoparticle
Nanoparticles
Nanostructure
PEGylated nanomagnets
Polymers
Superhydrophilic coating
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fabrication of PEG coating on magnetite nanoparticles (MNPs) is one of the most favoured ways to ensure biocompatibility. Surface modification of magnetite by an own-prepared comb-like PEG-copolymer (PEGA-AA) was compared with two commercially available ones (carboxy-PEG (PEG-C) and phosphate-PEG (PEG-P)). ATR FT-IR data revealed that all polymers form complexes on the surface of MNPs. Electrophoresis and dynamic light scattering (DLS) experiments showed that both the type and quantity of the polymers' anchoring groups influence the aggregation of coated nanomagnets. PEG-C shell does not provide excess negative charges, so magnetite particles became aggregated. However PEG-P and PEGA-AA gradually modify the surface: neutralizing the originally positively charged MNPs below loading 0.5mmol/g, while above it a polyanionic layer forms on nanomagnets dispersing them in salty media at pH ~6.5. The PEGA-AA comb-like copolymer is more efficient for MNPs PEGylation due to the uniform distribution of carboxylates and PEG chains along the carbon skeleton. •PEG-polymers were adsorbed through surface complexation on magnetite.•Increasing load of functionalized PEGs gradually modifies the MNP's surface.•MNPs coated completely by polyanionic shell can be dispersed in salty media at pH ~6.5.•Carboxylated comb-like PEG copolymer provides the most efficient biocompatible coating.
ISSN:0304-8853
DOI:10.1016/j.jmmm.2014.10.146