Carboxylic acid-functionalized SBA-15 nanorods for gemcitabine delivery

The present study deals with the functionalization of mesoporous silica nanoparticles as drug delivery systems. Mono, di, and tri amino-functionalized SBA-15 nanorods were synthesized by post-grafting method using (3-aminopropyl) triethoxysilane, N -(2-aminoethyl-)3- aminopropyltrimethoxysilane, and...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2015-03, Vol.17 (3), p.1-12, Article 125
Main Authors: Bahrami, Zohreh, Badiei, Alireza, Ziarani, Ghodsi Mohammadi
Format: Article
Language:English
Subjects:
Adsorption
Anhydrides
Carboxylic acids
Characterization and Evaluation of Materials
Chemistry and Materials Science
Derivatives
Drug delivery systems
Drugs
Inorganic Chemistry
Lasers
Materials Science
Nanoparticles
Nanorods
Nanostructure
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Research Paper
Silica
Surface chemistry
Thermogravimetric analysis
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Summary:The present study deals with the functionalization of mesoporous silica nanoparticles as drug delivery systems. Mono, di, and tri amino-functionalized SBA-15 nanorods were synthesized by post-grafting method using (3-aminopropyl) triethoxysilane, N -(2-aminoethyl-)3- aminopropyltrimethoxysilane, and 3-[2-(2-aminoethylamino) ethylamino] propyl trimethoxysilane, respectively. The carboxylic acid derivatives of the amino-functionalized samples were obtained using succinic anhydride. Tminopropyltrimethoxysilanehe obtained modified materials were investigated as matrixes for the anticancer drug (gemcitabine) delivery. The prepared samples were characterized by SAXS, N 2 adsorption/desorption, SEM, transmission electron microscopy, thermogravimetric analysis, and FTIR and UV spectroscopies. The adsorption and release properties of all samples were studied. It was revealed that the adsorption capacity and release behavior of gemcitabine were highly dependent on the type of the introduced functional groups. The carboxylic acid-modified samples have higher loading content, due to the strong interaction with gemcitabine. The maximum content of deposited drug in the modified SBA-15 nanorods is close to 40 wt%. It was found that the surface functionalization leads toward significant decrease of the drug release rate. The carboxylic acid-functionalized samples have slower release rate in contrast with the amino-functionalized samples.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-015-2929-1