Characteristics of Surface Behavior and Osteoinductivity of Biomimetic Ceramic Scaffold

We previously reported functionally graded hydroxyapatite (fg-HAp) with the characteristics of blood permeability into the bulk and osteoinduction by adding low dose of bone morphogenetic protein-2 (BMP-2). In this study, we evaluated the bioactivity of the obtained dense HAp bodies in a simulated b...

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Bibliographic Details
Published in:Key engineering materials 2013-01, Vol.529-530, p.50-54
Main Authors: Yamamoto, M., Minamida, Y., Hino, J., Tazaki, Junichi, Ito, K., Akazawa, Toshiyuki, Nagayasu, H., Shibata, T., Murata, Masaru, Tabata, Y., Arisue, M.
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bones
Formations
Functionally gradient materials
Permeation
Surface chemistry
Surgical implants
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Summary:We previously reported functionally graded hydroxyapatite (fg-HAp) with the characteristics of blood permeability into the bulk and osteoinduction by adding low dose of bone morphogenetic protein-2 (BMP-2). In this study, we evaluated the bioactivity of the obtained dense HAp bodies in a simulated body fluid (SBF) and the osteoinductive activity with or without SBF treatment in vivo. The fg-HApSBF was prepared by immersing the fg-HAp in the SBF solution at 14 days and the surface structure was observed by SEM. The fg-HApSBF showed fine bone-like crystal on the surface of the HAp. Ectopic bone formation occurred in the fg-HAp/BMP-2 (1.0, 0.5μg) system at 3 weeks, while only in the fg-HApSBF/BMP-2 (1.0μg), bone induction was found. The histological finding showed body fluid permeation into the fg-HApSBF bulk and bone formation were obserbed.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.529-530.50