Non-labeling multiplex surface enhanced Raman scattering (SERS) detection of volatile organic compounds (VOCs)

• Published in: Analytica chimica acta 2014-09, Vol.844, p.54-60
• Main Authors: Wong, Chi Lok, Dinish, U.S., Schmidt, Michael Stenbæk, Olivo, Malini
• Format: Article
• Language: English
• Subjects: Acetone; Chromatography, Liquid - methods; Ethanol; Ethyl alcohol; Homeland security; Limit of Detection; Multiplex detection; Multiplexing; Nanostructure; Non-labeling; Raman scattering; SERS; Spectrum Analysis, Raman - methods; Surface enhanced Raman scattering; Tandem Mass Spectrometry - methods; Volatile organic compounds; Volatile organic compounds (VOCs) detection; Volatile Organic Compounds - analysis
• ISSN: 0003-2670; 1873-4324
• DOI: 10.1016/j.aca.2014.06.043

[Display omitted] •We report multiplex SERS based VOCs detection with leaning nano-pillar substrate.•VOCs molecules adsorbed at the tip of the nano-pillars produce SERS signal.•Multiplex detection for the mixture of acetone and ethanol vapor is demonstrated.•To the best of our knowledge, it is the first SERS based multiplex VOCs detection.•The detection limits are 0.0017ng (ethanol vapor) and 0.0037ng (acetone vapor). In this paper, we report multiplex SERS based VOCs detection with a leaning nano-pillar substrate. The VOCs analyte molecules adsorbed at the tips of the nano-pillars produced SERS signal due to the field enhancement occurring at the localized surface plasmon hot spots between adjacent leaning nano-pillars. In this experiment, detections of acetone and ethanol vapor at different concentrations were demonstrated. The detection limits were found to be 0.0017ng and 0.0037ng for ethanol and acetone vapor molecules respectively. Our approach is a non-labeling method such that it does not require the incorporation of any chemical sensing layer for the enrichment of gas molecules on sensor surface. The leaning nano-pillar substrate also showed highly reproducible SERS signal in cyclic VOCs detection, which can reduce the detection cost in practical applications. Further, multiplex SERS detection on different combination of acetone and ethanol vapor was also successfully demonstrated. The vibrational fingerprints of molecular structures provide specific Raman peaks for different VOCs contents. To the best of our knowledge, this is the first multiplex VOCs detection using SERS. We believe that this work may lead to a portable device for multiplex, specific and highly sensitive detection of complex VOCs samples that can find potential applications in exhaled breath analysis, hazardous gas analysis, homeland security and environmental monitoring.