Immunogenicity and clinical protection against equine influenza by DNA vaccination of ponies

Highlights ► DNA vaccines expressing the HA gene of equine H3N8 influenza virus were generated. ► DNA vaccines elicit homologous and heterologous immune responses after 3 vaccinations. ► DNA vaccines protect against disease and viral replication following H3N8 challenge. ► Needle-free delivery is as...

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Bibliographic Details
Published in:Vaccine 2012-06, Vol.30 (26), p.3965-3974
Main Authors: Ault, Alida, Zajac, Alyse M, Kong, Wing-Pui, Gorres, J. Patrick, Royals, Michael, Wei, Chih-Jen, Bao, Saran, Yang, Zhi-yong, Reedy, Stephanie E, Sturgill, Tracy L, Page, Allen E, Donofrio-Newman, Jennifer, Adams, Amanda A, Balasuriya, Udeni B.R, Horohov, David W, Chambers, Thomas M, Nabel, Gary J, Rao, Srinivas S
Format: Article
Language:English
Subjects:
Allergy and Immunology
Amino acids
Animals
Antibodies, Viral - blood
Deoxyribonucleic acid
Dilution
DNA
DNA vaccine
DNA vaccines
Economics
Efficiency
Equine
equine influenza
Hemagglutinin Glycoproteins, Influenza Virus - genetics
Hemagglutinin Glycoproteins, Influenza Virus - immunology
Hemagglutinins
Horse Diseases - prevention & control
Horses
Immune response
Immunity
Immunization
Immunogenicity
Infection
Infections
Influenza
Influenza A virus
Influenza A Virus, H3N8 Subtype - genetics
Influenza A Virus, H3N8 Subtype - immunology
Influenza Vaccines - administration & dosage
Influenza Vaccines - adverse effects
Influenza Vaccines - isolation & purification
Influenza virus
Laboratory animals
Licenses
Methods
Mice
Morbidity
Mortality
neutralization
Orthomyxoviridae Infections - prevention & control
Orthomyxoviridae Infections - veterinary
Plasmids
Protection
recombinant vaccines
Replication
Studies
Swine flu
Syringes
vaccination
Vaccination - adverse effects
Vaccination - methods
vaccine development
Vaccines
Vaccines, DNA - administration & dosage
Vaccines, DNA - adverse effects
Vaccines, DNA - immunology
virus replication
Viruses
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Description
Summary:Highlights ► DNA vaccines expressing the HA gene of equine H3N8 influenza virus were generated. ► DNA vaccines elicit homologous and heterologous immune responses after 3 vaccinations. ► DNA vaccines protect against disease and viral replication following H3N8 challenge. ► Needle-free delivery is as efficient and effective as conventional needle/syringe. ► DNA vaccines are a safe, effective alternative for veterinary vaccines against flu.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.03.026