Ophirapstanol Trisulfate, a New Biologically Active Steroid Sulfate from the Deep Water Marine Sponge Topsentia ophiraphidites

Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-12, Vol.57 (12), p.1751-1754
Main Authors: Gunasekera, Sarath P, Sennett, Susan H, Kelly-Borges, Michelle, Bryant, Robert W
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Animals
ANTINEOPLASTIC AGENTS
BINDING PROTEINS
BIOASSAYS
CHEMICAL COMPOSITION
CHEMICAL REACTIONS
Circular Dichroism
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DOSAGE BIOLOGIQUE
ENSAYO BIOLOGICO
ESPECTROMETRIA
ESTEROIDES
Genes, ras - drug effects
GOLFE DU MEXIQUE
GOLFO DE MEXICO
GUANOSINE DIPHOSPHATE
guanosine diphosphate/g-protein ras exchange assay
GULF OF MEXICO
Humans
Magnetic Resonance Spectroscopy
Marine
MEDICAMENT CYTOSTATIQUE
MEDICINAL PROPERTIES
MOLECULAR CONFORMATION
molecular structure
Mutagenicity Tests
Mutagens - isolation & purification
Mutagens - toxicity
NUCLEOTIDE
NUCLEOTIDES
NUCLEOTIDOS
PARAZOA
Porifera - chemistry
PROPIEDADES MEDICINALES
PROPRIETE PHARMACOLOGIQUE
PROTEINAS AGLUTINANTES
PROTEINE DE LIAISON
REACCIONES QUIMICAS
REACTION CHIMIQUE
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STEROIDE
STEROIDS
Sterols - isolation & purification
Sterols - toxicity
Sulfuric Acid Esters - isolation & purification
Sulfuric Acid Esters - toxicity
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Description
Summary:Ophirapstanol trisulfate [1], a new steroid trisulfate related to sokotrasterol trisulfate was isolated from a deep water marine sponge Topsentia ophiraphidites. Compound 1 exhibited significant inhibition in the guanosine diphosphate/G-protein RAS exchange assay. The structure elucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50114a024