Fornix triamcinolone injection for thyroid orbitopathy

Purpose In this pilot study we aimed to examine the association between eyelid fornices triamcinolone injections and clinical activity score in patients with active thyroid orbitopathy. Methods Adult patients aged 18 years or older, diagnosed with active thyroid orbitopathy and a clinical activity s...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2015-05, Vol.253 (5), p.811-816
Main Authors: Hamed-Azzam, Shirin, Mukari, Abed, Feldman, Ilan, Saliba, Walid, Jabaly-Habib, Haneen, Briscoe, Daniel
Format: Article
Language:English
Subjects:
Eyelids
Female
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Glycated Hemoglobin A - analysis
Graves Ophthalmopathy - diagnosis
Graves Ophthalmopathy - drug therapy
Graves Ophthalmopathy - physiopathology
Humans
Injections, Intraocular
Male
Medicine
Medicine & Public Health
Middle Aged
Oculomotor Muscles - diagnostic imaging
Oculoplastics and Orbit
Ophthalmology
Orbital Diseases - diagnosis
Orbital Diseases - drug therapy
Orbital Diseases - physiopathology
Pilot Projects
Prospective Studies
Triamcinolone Acetonide - adverse effects
Triamcinolone Acetonide - therapeutic use
Ultrasonography
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Summary:Purpose In this pilot study we aimed to examine the association between eyelid fornices triamcinolone injections and clinical activity score in patients with active thyroid orbitopathy. Methods Adult patients aged 18 years or older, diagnosed with active thyroid orbitopathy and a clinical activity score ≥3 were recruited to this interventional prospective pilot study between 2010 and 2013. Three upper and lower fornices injections of triamcinolone acetate 20 mg (40 mg/ml) were administered at 4-week intervals. Each patient included was followed up for a period of 6 months. Clinical activity score was estimated at each monthly visit. Extraocular muscle thickness was measured by ultrasound examination at entrance and at the last visit. Results Eleven eyes of seven patients were included in our study. Initial clinical activity score was 3.81 ± 1.80 and fell to 0.63 ± 0.72 during a 6-month follow-up. There was a significant difference in clinical activity score between the baseline examination and the following visits (p-value 
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-015-2957-7