Dependance of the ultrastructural changes in cortical synapses on the time interval between associated neurochemical signals

• Published in: Neuroscience and behavioral physiology 1992-11, Vol.22 (6), p.473-475
• Main Authors: Khludova, G. G., Myasnikov, A. A., Lyal'ka, V. F.
• Format: Article
• Language: English
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/BF01185436

The present study is devoted to the investigation of the mechanisms of the interaction of neurochemical signals at the level of the synapses of neurons. The data of our preceding investigations suggest that the combined microapplications of glutamic acid (GLU) and acetylcholine (AC) to the sensorimotor area of the cerebral cortex of rats leads to a significant increase in the thickness of postsynaptic enlargements (PSE) of the synapses of neurons found in the zone of the applications. A relationship was also identified for this pair of mediators of the magnitude of the structural modifications of the synapses to the lag time of AC relative to GLU. A significant (by comparison with the effects of the control, noncombined applications of the same substances) increase of the thickness of the PSE in the synapses of this tissue was also identified by us in the course of the associated influences on microregions of the cortical tissue of GLU and a different mediator, norepinephrine (NE) with a time lag of NE of 1 sec. The relationship of the direction and degree of manifestation of the modifications of these postsynaptic neuronal structures and the time lag of NE relative to GLU when they are locally and repeatedly applied in combination was investigated in the present study.