Baclofen administration for the treatment of affective disorders in alcoholic patients

• Published in: Drug and alcohol dependence 1993-09, Vol.33 (2), p.157-163
• Main Authors: Krupitsky, E.M., Burakov, A.M., Ivanov, V.B., Krandashova, G.F., Lapin, I.P., Ja Grinenko, A., Borodkin, Yu.S.
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adult; alcoholism; Alcoholism - enzymology; Alcoholism - psychology; Alcoholism - rehabilitation; Amitriptyline - administration & dosage; anxiety; Anxiety Disorders - enzymology; Anxiety Disorders - psychology; Anxiety Disorders - rehabilitation; baclofen; Baclofen - administration & dosage; Blood Platelets - drug effects; Blood Platelets - enzymology; depression; Depressive Disorder - enzymology; Depressive Disorder - psychology; Depressive Disorder - rehabilitation; Diazepam - administration & dosage; Dopamine - blood; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid - blood; Humans; Male; Monoamine Oxidase - blood; Personality Inventory; Receptors, GABA-A - drug effects; Receptors, GABA-A - physiology; Receptors, GABA-B - drug effects; Receptors, GABA-B - physiology; Serotonin - blood
• ISSN: 0376-8716; 1879-0046
• DOI: 10.1016/0376-8716(93)90057-W

Ninety alcoholic patients with the secondary affective disorders (anxiety, depression) were divided into four groups. Patients in the first group received GABAB receptor ligands (baclofen), those in the second group, diazepam, those in the third group, amitriptyline and those in the fourth group, placebo. The results of clinical, psychological (tests of Spielberger, Zung and MMPI), and electrophysiological (superslow ω-potential) investigations showed that baclofen is an effective drug for affective disturbances in alcoholic patients, with efficacy superior to placebo and equal to diazepam and amitriptyline. At the same time baclofen does not have the side-effects and complications of the latter. Significant changes in platelet MAO Bactivity and the dopamine, serotonin and GABA concentrations in blood after treatment were not found in the four patient groups. The peripheral matabolism of GABA and monoamines do not seem to be related to the development of secondary affective disorders in alcoholic patients. This investigation encourages the search for drugs acting on the affective psychopathology of GABA B receptor ligands.