A comparison of the accumulation of novobiocin into bacteria with its antibacterial properties

The accumulation of novobiocin in bacteria has been compared with the MIC, inhibition of DNA biosynthesis and inhibition of the activity of isolated DNA gyrase for a range of species. There was a good correlation between MIC and the inhibition of DNA biosynthesis and DNA gyrase. Novobiocin accumulat...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1994-12, Vol.34 (6), p.1041-1045
Main Authors: Barrett-Bee, Keith, Pinder, Philip, Stawpert, John
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria - drug effects
Bacteria - enzymology
Bacteria - genetics
Biological and medical sciences
DNA Topoisomerases, Type I - drug effects
DNA, Bacterial - biosynthesis
DNA, Bacterial - drug effects
Medical sciences
Microbial Sensitivity Tests
Novobiocin - pharmacology
Permeability
Pharmacology. Drug treatments
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Summary:The accumulation of novobiocin in bacteria has been compared with the MIC, inhibition of DNA biosynthesis and inhibition of the activity of isolated DNA gyrase for a range of species. There was a good correlation between MIC and the inhibition of DNA biosynthesis and DNA gyrase. Novobiocin accumulation did not correlate with any other parameter.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/34.6.1041