Enhancement of Antigen-Induced T-Cell Proliferation by Soluble CD26/ Dipeptidyl Peptidase IV

The addition of a soluble recombinant CD26 (sCD26) enhanced proliferation of peripheral blood lymphocytes induced by the recall antigen tetanus toxoid. sCD26 itself did not provide a mitogenic signal and did not augment the proliferative response of T cells to other mitogenic stimuli such as phytohe...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (8), p.3082-3086
Main Authors: TANAKA, T, DUKE-COHAN, J. S, KAMEOKA, J, YARON, A, LEE, I, SCHLOSSMAN, S. F, MORIMOTO, C
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Amino Acid Sequence
Amino acids
Antibodies
Antigens
Antigens, Differentiation, T-Lymphocyte - chemistry
Antigens, Differentiation, T-Lymphocyte - immunology
Biological and medical sciences
Blood plasma
Cell lines
CHO cells
Complementary DNA
Dipeptidyl Peptidase 4
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - chemistry
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - immunology
Enzyme activity
Enzymes
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunity (Disease)
Immunobiology
In Vitro Techniques
Lymphocyte Activation
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
Molecular Sequence Data
Molecules
Peptides - immunology
Proteins
Solubility
Structure-Activity Relationship
T lymphocytes
T-Lymphocytes - immunology
Tetanus Toxoid - immunology
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Summary:The addition of a soluble recombinant CD26 (sCD26) enhanced proliferation of peripheral blood lymphocytes induced by the recall antigen tetanus toxoid. sCD26 itself did not provide a mitogenic signal and did not augment the proliferative response of T cells to other mitogenic stimuli such as phytohemagglutinin and anti-CD3. Dipeptidyl peptidase IV-negative sCD26 did not have this enhancement effect, implying a requirement for enzyme activity. It was found that there exists a large variation in the levels of human plasma sCD26/dipeptidyl peptidase IV in vivo which may regulate T-cell activity. Peripheral blood lymphocytes from individuals whose plasma sCD26 was high and responded strongly to tetanus toxoid stimulation were insensitive to the enhancing effects of exogenously added sCD26. This suggests that plasma sCD26 had modulated the responsiveness of T cells of these individuals in vivo and that the endogenous plasma sCD26 regulates immune responses by allowing antigen-specific T cells to exert a maximal response to their specific antigen.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.91.8.3082