Loading…

Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake

Background/Objectives: The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3–7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8–11 years. To ensure t...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical nutrition 2015-02, Vol.69 (2), p.234-241
Main Authors: Christian, M S, Evans, C E L, Nykjaer, C, Hancock, N, Cade, J E
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393
cites cdi_FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393
container_end_page 241
container_issue 2
container_start_page 234
container_title European journal of clinical nutrition
container_volume 69
creator Christian, M S
Evans, C E L
Nykjaer, C
Hancock, N
Cade, J E
description Background/Objectives: The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3–7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8–11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods: A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t -tests and Pearson’s r correlations. Bland–Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables ( r =0.7). The results from the Bland–Altman plots revealed a mean difference of 54 g (95% confidence interval: −88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children’s diets. Conclusions: The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3–11 years with a focus on fruit and vegetable intake.
doi_str_mv 10.1038/ejcn.2014.160
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680171888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A400415460</galeid><sourcerecordid>A400415460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393</originalsourceid><addsrcrecordid>eNqN0s9v0zAUB_AIgdgYHLkiS0hoHFLs-Fe8W9WVH9IQl3KOXOelcXHtYidD-3f4S3FYYQNVCOUQKfq8l_fsb1E8J3hGMK3fwNb4WYUJmxGBHxSnhElRcsHww-IUK85KirE8KZ6ktMVZSVk9Lk4qTqjivD4tvn8EncZo_Qa1FgZkPdpHu9PxBiXTh-CQ6a1rI3ikN9CiuiQE3YCO6QJda2dbPdjgUejQ0ANaTBZp36LLqdkyi_EWrKZW54v55XL1Gn2zQ58Vgt2-18kmlEEXRzv8LL2GDQx67SAPM-gv8LR41GmX4NnhfVZ8frtcLd6XV5_efVjMr0ojKjWURBi8ph1WTPCuEkIKjmXF1pWpWadNJ6XQIDDFWhFQrWJacsaZACoIMKroWXF-23cfw9cR0tDsbDLgnPYQxtQQUWMiSV3X_0F5xTitKpnpy7_oNozR50WailIiqFL5Mv6hci-sJFWE3amNdtBY34UhajP9upkzjBnJ6-CsyiNqAx6idsFDZ_PnP_zsiM9PCztrjha8ulfQg3ZDn4Ibp4tORycxMaQUoWsO2WoIbqb0NlN6mym9ec3JvzicwrjeQftb_4rr3ahpP0UW4r1jOtrxB_tD8_Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1650973914</pqid></control><display><type>article</type><title>Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake</title><source>Springer Nature</source><source>EZB Electronic Journals Library</source><creator>Christian, M S ; Evans, C E L ; Nykjaer, C ; Hancock, N ; Cade, J E</creator><creatorcontrib>Christian, M S ; Evans, C E L ; Nykjaer, C ; Hancock, N ; Cade, J E</creatorcontrib><description>Background/Objectives: The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3–7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8–11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods: A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t -tests and Pearson’s r correlations. Bland–Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables ( r =0.7). The results from the Bland–Altman plots revealed a mean difference of 54 g (95% confidence interval: −88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children’s diets. Conclusions: The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3–11 years with a focus on fruit and vegetable intake.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2014.160</identifier><identifier>PMID: 25139558</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/700/1720 ; 692/700/2814 ; Child ; Children ; Children &amp; youth ; Clinical Nutrition ; Confidence intervals ; Correlation analysis ; Diaries ; Diet ; Diet Records ; Elementary school students ; Energy Intake ; Epidemiology ; Evaluation ; Feeding Behavior ; Female ; Food ; Food and nutrition ; Food intake ; Fruit ; Fruits ; Health aspects ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine &amp; Public Health ; Metabolic Diseases ; Nutrients ; Nutrition ; Nutrition Assessment ; Obesity ; original-article ; Portion Size ; Public Health ; Reproducibility of Results ; Schools ; Surveys and Questionnaires ; United Kingdom ; Vegetables</subject><ispartof>European journal of clinical nutrition, 2015-02, Vol.69 (2), p.234-241</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393</citedby><cites>FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25139558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christian, M S</creatorcontrib><creatorcontrib>Evans, C E L</creatorcontrib><creatorcontrib>Nykjaer, C</creatorcontrib><creatorcontrib>Hancock, N</creatorcontrib><creatorcontrib>Cade, J E</creatorcontrib><title>Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/Objectives: The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3–7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8–11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods: A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t -tests and Pearson’s r correlations. Bland–Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables ( r =0.7). The results from the Bland–Altman plots revealed a mean difference of 54 g (95% confidence interval: −88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children’s diets. Conclusions: The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3–11 years with a focus on fruit and vegetable intake.</description><subject>692/700/1720</subject><subject>692/700/2814</subject><subject>Child</subject><subject>Children</subject><subject>Children &amp; youth</subject><subject>Clinical Nutrition</subject><subject>Confidence intervals</subject><subject>Correlation analysis</subject><subject>Diaries</subject><subject>Diet</subject><subject>Diet Records</subject><subject>Elementary school students</subject><subject>Energy Intake</subject><subject>Epidemiology</subject><subject>Evaluation</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Food</subject><subject>Food and nutrition</subject><subject>Food intake</subject><subject>Fruit</subject><subject>Fruits</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Obesity</subject><subject>original-article</subject><subject>Portion Size</subject><subject>Public Health</subject><subject>Reproducibility of Results</subject><subject>Schools</subject><subject>Surveys and Questionnaires</subject><subject>United Kingdom</subject><subject>Vegetables</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqN0s9v0zAUB_AIgdgYHLkiS0hoHFLs-Fe8W9WVH9IQl3KOXOelcXHtYidD-3f4S3FYYQNVCOUQKfq8l_fsb1E8J3hGMK3fwNb4WYUJmxGBHxSnhElRcsHww-IUK85KirE8KZ6ktMVZSVk9Lk4qTqjivD4tvn8EncZo_Qa1FgZkPdpHu9PxBiXTh-CQ6a1rI3ikN9CiuiQE3YCO6QJda2dbPdjgUejQ0ANaTBZp36LLqdkyi_EWrKZW54v55XL1Gn2zQ58Vgt2-18kmlEEXRzv8LL2GDQx67SAPM-gv8LR41GmX4NnhfVZ8frtcLd6XV5_efVjMr0ojKjWURBi8ph1WTPCuEkIKjmXF1pWpWadNJ6XQIDDFWhFQrWJacsaZACoIMKroWXF-23cfw9cR0tDsbDLgnPYQxtQQUWMiSV3X_0F5xTitKpnpy7_oNozR50WailIiqFL5Mv6hci-sJFWE3amNdtBY34UhajP9upkzjBnJ6-CsyiNqAx6idsFDZ_PnP_zsiM9PCztrjha8ulfQg3ZDn4Ibp4tORycxMaQUoWsO2WoIbqb0NlN6mym9ec3JvzicwrjeQftb_4rr3ahpP0UW4r1jOtrxB_tD8_Q</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Christian, M S</creator><creator>Evans, C E L</creator><creator>Nykjaer, C</creator><creator>Hancock, N</creator><creator>Cade, J E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope></search><sort><creationdate>20150201</creationdate><title>Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake</title><author>Christian, M S ; Evans, C E L ; Nykjaer, C ; Hancock, N ; Cade, J E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/700/1720</topic><topic>692/700/2814</topic><topic>Child</topic><topic>Children</topic><topic>Children &amp; youth</topic><topic>Clinical Nutrition</topic><topic>Confidence intervals</topic><topic>Correlation analysis</topic><topic>Diaries</topic><topic>Diet</topic><topic>Diet Records</topic><topic>Elementary school students</topic><topic>Energy Intake</topic><topic>Epidemiology</topic><topic>Evaluation</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Food</topic><topic>Food and nutrition</topic><topic>Food intake</topic><topic>Fruit</topic><topic>Fruits</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Metabolic Diseases</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Obesity</topic><topic>original-article</topic><topic>Portion Size</topic><topic>Public Health</topic><topic>Reproducibility of Results</topic><topic>Schools</topic><topic>Surveys and Questionnaires</topic><topic>United Kingdom</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christian, M S</creatorcontrib><creatorcontrib>Evans, C E L</creatorcontrib><creatorcontrib>Nykjaer, C</creatorcontrib><creatorcontrib>Hancock, N</creatorcontrib><creatorcontrib>Cade, J E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christian, M S</au><au>Evans, C E L</au><au>Nykjaer, C</au><au>Hancock, N</au><au>Cade, J E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>69</volume><issue>2</issue><spage>234</spage><epage>241</epage><pages>234-241</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/Objectives: The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3–7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8–11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods: A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t -tests and Pearson’s r correlations. Bland–Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables ( r =0.7). The results from the Bland–Altman plots revealed a mean difference of 54 g (95% confidence interval: −88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children’s diets. Conclusions: The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3–11 years with a focus on fruit and vegetable intake.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25139558</pmid><doi>10.1038/ejcn.2014.160</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0954-3007
ispartof European journal of clinical nutrition, 2015-02, Vol.69 (2), p.234-241
issn 0954-3007
1476-5640
language eng
recordid cdi_proquest_miscellaneous_1680171888
source Springer Nature; EZB Electronic Journals Library
subjects 692/700/1720
692/700/2814
Child
Children
Children & youth
Clinical Nutrition
Confidence intervals
Correlation analysis
Diaries
Diet
Diet Records
Elementary school students
Energy Intake
Epidemiology
Evaluation
Feeding Behavior
Female
Food
Food and nutrition
Food intake
Fruit
Fruits
Health aspects
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Nutrients
Nutrition
Nutrition Assessment
Obesity
original-article
Portion Size
Public Health
Reproducibility of Results
Schools
Surveys and Questionnaires
United Kingdom
Vegetables
title Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T19%3A19%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Measuring%20diet%20in%20primary%20school%20children%20aged%208-11%20years:%20validation%20of%20the%20Child%20and%20Diet%20Evaluation%20Tool%20(CADET)%20with%20an%20emphasis%20on%20fruit%20and%20vegetable%20intake&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Christian,%20M%20S&rft.date=2015-02-01&rft.volume=69&rft.issue=2&rft.spage=234&rft.epage=241&rft.pages=234-241&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2014.160&rft_dat=%3Cgale_proqu%3EA400415460%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c629t-16c0b3f09465f2667650724b2c84facf776ae6030a91e9d94a754546e361e4393%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1650973914&rft_id=info:pmid/25139558&rft_galeid=A400415460&rfr_iscdi=true