Arterial and portal venous liver perfusion using selective spin labelling MRI

• Published in: European radiology 2015-06, Vol.25 (6), p.1529-1540
• Main Authors: Schalkx, Hanke J., Petersen, Esben T., Peters, Nicky H. G. M., Veldhuis, Wouter B., van Leeuwen, Maarten S., Pluim, Josien P. W., van den Bosch, Maurice A. A. J., van Stralen, Marijn
• Format: Article
• Language: English
• Subjects: Adult; Contraindications; Contrast agents; Diagnostic Radiology; Feasibility Studies; Female; Hepatobiliary-Pancreas; Humans; Imaging; Internal Medicine; Interventional Radiology; Labeling; Liver - blood supply; Liver Circulation - physiology; Liver diseases; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Mesenteric Artery, Superior - physiology; Neuroradiology; Portal Vein - physiology; Postprandial Period - physiology; Radiology; Reference Values; Reproducibility; Reproducibility of Results; Spin Labels; Ultrasound; Veins & arteries
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-014-3524-z

Purpose To investigate the feasibility of selective arterial and portal venous liver perfusion imaging with spin labelling (SL) MRI, allowing separate labelling of each blood supply. Methods The portal venous perfusion was assessed with a pulsed EPISTAR technique and the arterial perfusion with a pseudo-continuous sequence. To explore precision and reproducibility, portal venous and arterial perfusion were separately quantified in 12 healthy volunteers pre- and postprandially (before and after meal intake). In a subgroup of 6 volunteers, the accuracy of the absolute portal perfusion and its relative postprandial change were compared with MRI flow measurements of the portal vein. Results The portal venous perfusion significantly increased from 63 ± 22 ml/100g/min preprandially to 132 ± 42 ml/100g/min postprandially. The arterial perfusion was lower with 35 ± 22 preprandially and 22 ± 30 ml/100g/min postprandially. The pre- and postprandial portal perfusion using SL correlated well with flow-based perfusion (r 2  = 0.71). Moreover, postprandial perfusion change correlated well between SL- and flow-based quantification (r 2  = 0.77). The SL results are in range with literature values. Conclusion Selective spin labelling MRI of the portal venous and arterial blood supply successfully quantified liver perfusion. This non-invasive technique provides specific arterial and portal venous perfusion imaging and could benefit clinical settings where contrast agents are contraindicated. Key Points • Perfusion imaging of the liver by Spin Labelling MRI is feasible • Selective Spin Labelling MRI assessed portal venous and arterial liver perfusion separately • Spin Labelling based portal venous liver perfusion showed significant postprandial increase • Spin Labelling based portal perfusion correlated well with phase - contrast based portal perfusion • This non - invasive technique could benefit settings where contrast agents are contraindicated