Circulating MKRN3 Levels Decline Prior to Pubertal Onset and Through Puberty: A Longitudinal Study of Healthy Girls

Context: Puberty is initiated by a complex interaction of suppressing and stimulating factors. Genetic studies of familial central precocious puberty have suggested makorin ring finger protein 3 (MKRN3) as a major inhibitor of GnRH secretion during childhood. Furthermore, genetic variation near MKRN...

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Published in:The journal of clinical endocrinology and metabolism 2015-05, Vol.100 (5), p.1920-1926
Main Authors: Hagen, Casper P, Sørensen, Kaspar, Mieritz, Mikkel G, Johannsen, Trine Holm, Almstrup, Kristian, Juul, Anders
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Female
Follicle Stimulating Hormone - blood
Genotype
Healthy Volunteers
Humans
Longitudinal Studies
Luteinizing Hormone - blood
Prospective Studies
Puberty - blood
Puberty, Precocious - blood
Ribonucleoproteins - blood
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Summary:Context: Puberty is initiated by a complex interaction of suppressing and stimulating factors. Genetic studies of familial central precocious puberty have suggested makorin ring finger protein 3 (MKRN3) as a major inhibitor of GnRH secretion during childhood. Furthermore, genetic variation near MKRN3 (rs12148769) affects age at menarche in healthy girls. Objective: The purpose of this study was to evaluate whether serum levels of MKRN3 declined before pubertal onset in healthy girls. Design: This was a population-based longitudinal study of healthy Danish girls and a cohort study of early maturing girls. Setting: The study was performed in the general community and in a tertiary referral center for pediatric endocrinology. Patients or Other Participants: Healthy girls (n = 38) aged 9.3 years (range, 5.9–11.3 years) at baseline and followed for 6.0 years (2.7–7.6 years) (2006–2014) with blood sampling every 6 months and early maturing girls (n = 13) with breast development ay
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2014-4462