Mitotic Spindle Orientation: Semaphorin-Plexin Signaling Flags the Way

The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation criti...

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Bibliographic Details
Published in:Developmental cell 2015-05, Vol.33 (3), p.243-244
Main Authors: Humbert, Patrick O., Gödde, Nathan J.
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion Molecules - metabolism
Cell Division - physiology
Kidney - metabolism
Male
Morphogenesis - physiology
Nerve Tissue Proteins - metabolism
Semaphorins - metabolism
Signal Transduction
Spindle Apparatus - metabolism
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Summary:The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney development and repair.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2015.04.012