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Role of PMK-1/p38 MAPK defense in Caenorhabditis elegans against Klebsiella pneumoniae infection during host–pathogen interaction

The present study reports that Klebsiella pneumoniae (KP) killed the Caenorhabditis elegans as a consequence of an accumulation and proliferation of the pathogen inside the worms’ intestine. The real-time PCR analysis of the genes responsible for vulval development (let-23) and egg laying (lin-29) i...

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Bibliographic Details
Published in:Pathogens and disease 2015-07, Vol.73 (5)
Main Authors: Kamaladevi, Arumugam, Balamurugan, Krishnaswamy
Format: Article
Language:English
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Summary:The present study reports that Klebsiella pneumoniae (KP) killed the Caenorhabditis elegans as a consequence of an accumulation and proliferation of the pathogen inside the worms’ intestine. The real-time PCR analysis of the genes responsible for vulval development (let-23) and egg laying (lin-29) in KP infected C. elegans confirmed the reproductive defects provoked by KP at the molecular level. In addition, the genetic analysis in N2 wild type, tol-1, sek-1 and pmk-1 mutants unveiled that KP attenuates the toll-dependent p38 mitogen-activated protein kinase (p38 MAPK) by chiefly inhibiting the production of antimicrobial factors such as nlp-29, lys-1 and C-type lectins. Conclusively, the surrendering of the host immune system appears to be attenuated by the toll-dependent p38 MAPK pathway regulation in C. elegans. This report deciphers that the Caenorhabditis elegans immune response against Klebsiella pneumoniae infection is of greater interest.
ISSN:2049-632X
2049-632X
DOI:10.1093/femspd/ftv021