Impact of radiation history, gender and age on bone quality in sites for orthodontic skeletal anchorage device placement

• Published in: Annals of anatomy 2015-05, Vol.199, p.67-72
• Main Authors: Konermann, A., Appel, T., Wenghoefer, M., Sirokay, S., Dirk, C., Jäger, A., Götz, W.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - physiology; Biopsy; Bone and Bones - radiation effects; Bone Marrow - anatomy & histology; Bone Neoplasms - radiotherapy; Bone quality; Bone Screws; Dental Implants; Female; Histomorphometry; Humans; Male; Mandible - radiation effects; Middle Aged; Orthodontic Anchorage Procedures - methods; Orthodontic miniscrews; Radiotherapy; Radiotherapy - adverse effects; Sex Characteristics; Young Adult
• ISSN: 0940-9602; 1618-0402
• DOI: 10.1016/j.aanat.2014.08.002

Stability of orthodontic miniscrew implants is prerequisite to their success and durability in orthodontic treatment. As investigations revealed a positive correlation of miniscrew stability to periimplant bone quality, it has been the aim of this study to analyze the bone structure of resection preparations of human mandibles histologically by investigating the samples according to age, gender and exposure to radiotherapy. Inflammation- and tumor-free alveolar bone sections from human mandibles (n=31) with previously diagnosed carcinoma, chronic osteomyelitis or cysts were analyzed histomorphologically and histomorphometrically as to the dimension of trabeculae in cancellous areas. Group A investigated the impact of a history of radiation therapy, group B of gender and group C contrasted biopsies from individuals aging under 60 or over 60 years. Statistics were performed using the Kruskal–Wallis-test. Radiation, gender and age did not significantly influence bone density. The mean bone density averaged 40.7±15.0% of spongiosa for the total collective with a median age of 58.4 years±14.7 years. Our findings provide new information on bone quality, thus contributing to a more precise evaluation of the parameters affecting and those not affecting miniscrew implant stability. On the basis of these results, the formulation of clinical guidelines for risk assessment of therapeutic approaches in patients prior to insertion of orthodontic skeletal anchorage devices seems to be conceivable.