Semi-Automated Nanoprecipitation-System—An Option for Operator Independent, Scalable and Size Adjustable Nanoparticle Synthesis

The preparation of nano-sized carrier systems increasingly moved into focus of pharmaceutical research and industry in the past decades. Besides the drug load and properties of the selected polymer/lipid, the size of such particles is one of the most important parameters regarding their use as effic...

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Bibliographic Details
Published in:Pharmaceutical research 2015-06, Vol.32 (6), p.1859-1863
Main Authors: Rietscher, René, Thum, Carolin, Lehr, Claus-Michael, Schneider, Marc
Format: Article
Language:English
Subjects:
Automation
Biochemistry
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Chemical Precipitation
Chemical synthesis
Chemistry, Pharmaceutical
Drug Carriers
Drug delivery systems
Equipment Design
Medical Law
Nanoparticles
Nanotechnology - instrumentation
Nanotechnology - methods
Perspectives
Pharmacology
Pharmacology/Toxicology
Pharmacy
Polyglactin 910 - chemistry
Syringes
Technology, Pharmaceutical - instrumentation
Technology, Pharmaceutical - methods
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Summary:The preparation of nano-sized carrier systems increasingly moved into focus of pharmaceutical research and industry in the past decades. Besides the drug load and properties of the selected polymer/lipid, the size of such particles is one of the most important parameters regarding their use as efficient drug delivery systems. However, the preparation of nanoparticles with different sizes in a controlled manner is challenging, especially in terms of reproducibility and scale-up possibility. To overcome these hurdles we developed a system relying on nanoprecipitation, which meets all these requirements of an operator independent, scalable and size-adjustable nanoparticle synthesis—the Semi-Automated Nanoprecipitation-System. This system enables the adaption of the particle size to specific needs based on the process parameters—injection rate, flow rate and polymer concentration—identified within this study. The basic set-up is composed of a syringe pump and a gear pump for a precise control of the flow and injection speed of the system. Furthermore, a home-made tube-straightener guarantees a curvature-free injection point. Thus it could be shown that the production of poly(lactide- co -glycolide) nanoparticles from 150 to 600 nm with a narrow size distribution in a controlled semi-automatic manner is possible.
ISSN:0724-8741
1573-904X
DOI:10.1007/s11095-014-1612-z