Inhibiting Interleukin-18 Production Through the Mitogen-Activated Protein Kinase Pathway, A Potential Role of Corticotropin-Releasing Hormone in Chronic Plaque Psoriasis

Corticotropin-releasing hormone (CRH) and CRH receptors (CRH-Rs) are expressed in the skin; CRH-R1 is the predominant receptor. Whether the CRH/CRH-R1 system plays a role in psoriasis has not yet been assessed. Immunohistochemistry, real-time RT-PCR, ELISA assay, and Western blot analysis were used...

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Bibliographic Details
Published in:Inflammation 2015-06, Vol.38 (3), p.1003-1011
Main Authors: Zhou, Chun-Lei, Yu, Xiao-Jing, Cai, Da-Xing, Xu, Yong-Hao, Li, Chun-Yang, Sun, Qing
Format: Article
Language:English
Subjects:
Adult
Biomedical and Life Sciences
Biomedicine
Cell Line
Corticotropin-Releasing Hormone - biosynthesis
Corticotropin-Releasing Hormone - pharmacology
Down-Regulation
Female
Humans
Immunology
Interleukin-18 - biosynthesis
Internal Medicine
Male
MAP Kinase Signaling System
Middle Aged
Mitogen-Activated Protein Kinases - metabolism
Pathology
Pharmacology/Toxicology
Psoriasis - pathology
Receptors, Corticotropin-Releasing Hormone - biosynthesis
Rheumatology
Skin - metabolism
Skin - pathology
Young Adult
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Summary:Corticotropin-releasing hormone (CRH) and CRH receptors (CRH-Rs) are expressed in the skin; CRH-R1 is the predominant receptor. Whether the CRH/CRH-R1 system plays a role in psoriasis has not yet been assessed. Immunohistochemistry, real-time RT-PCR, ELISA assay, and Western blot analysis were used to investigate the expression of CRH/CRH-R1 in patients with chronic plaque psoriasis and that of IL-18 in CRH-treated HaCaT cells. CRH and CRH-R1 were downregulated in patients with chronic plaque psoriasis. In vitro , CRH attenuated the expression of IL-18 by a mitogen-activated protein kinase signaling pathway through CRH-R1 in HaCaT cells. Thus, an aberrant cutaneous CRH/CRH-R1 system exists in lesions from chronic plaque psoriasis which might play a role in psoriasis and offers further evidence for the study of CRH in the skin.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-014-0064-2