The frequency and impact of FGFR1 amplification on clinical outcomes in Korean patients with small cell lung cancer

Highlights • FGFR1 amplification was rarely detected (1.9%) in Korean small cell lung cancer patients. • FGFR1 amplification was associated with shorter progression-free survival to first-line chemotherapy. • FGFR1 amplification may be a potential therapeutic target in small cell lung cancer.

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2015-06, Vol.88 (3), p.325-331
Main Authors: Park, Ji Soo, Lee, Jae-Seok, Kim, Eun Young, Jung, Ji Ye, Kim, Se Kyu, Chang, Joon, Kim, Dae Joon, Lee, Chang Young, Jung, Inkyung, Kim, Joo Hang, Kim, Hye Ryun, Moon, Yong Wha, Kim, Hyo Song, Cho, Byoung Chul, Shim, Hyo Sup
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Female
Follow-Up Studies
Gene Amplification
Hematology, Oncology and Palliative Medicine
Humans
In Situ Hybridization, Fluorescence
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Outcome Assessment (Health Care)
Prognosis
Pulmonary/Respiratory
Receptor, Fibroblast Growth Factor, Type 1 - genetics
Republic of Korea
Risk Factors
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - mortality
Small Cell Lung Carcinoma - pathology
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Description
Summary:Highlights • FGFR1 amplification was rarely detected (1.9%) in Korean small cell lung cancer patients. • FGFR1 amplification was associated with shorter progression-free survival to first-line chemotherapy. • FGFR1 amplification may be a potential therapeutic target in small cell lung cancer.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2015.03.002