Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal–epithelial transition

Highlights • MICAL-L2 is an important regulator of epithelial–mesenchymal transition (EMT) in ovarian cancer. • Silencing of MICAL-L2 inhibited Wnt/β-catenin pathway via preventing nuclear translocation of β-catenin. • MICAL-L2 is up-regulated in ovarian cancer tissues along with FIGO stage and asso...

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Bibliographic Details
Published in:Cancer letters 2015-07, Vol.363 (1), p.71-82
Main Authors: Zhu, Lin-Yan, Zhang, Wen-Ming, Yang, Xiao-Mei, Cui, Lining, Li, Jun, Zhang, Yan-Li, Wang, Ya-Hui, Ao, Jun-Ping, Ma, Ming-Ze, Lu, Huan, Ren, Yuan, Xu, Shao-Hua, Yang, Guang-Dong, Song, Wei-Wei, Wang, Jing-Hao, Zhang, Xiao-Dan, Zhang, Rong, Zhang, Zhi-Gang
Format: Article
Language:English
Subjects:
Animals
beta Catenin - metabolism
Cell Line, Tumor
Cell Movement
Cell Proliferation
Cysts
Cytoskeleton
EMT
Epithelial-Mesenchymal Transition - genetics
Female
Gene Expression Regulation, Neoplastic
Gynecology
Hematology, Oncology and Palliative Medicine
Humans
Invasion
Metastasis
MICAL-L2
Mice, Nude
Microfilament Proteins - genetics
Microfilament Proteins - metabolism
Neoplasm Invasiveness
Neoplasm Staging
Ovarian cancer
Ovarian Neoplasms - genetics
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Phenotype
Proliferation
Proteins
RNA Interference
Time Factors
Transfection
Wnt Signaling Pathway
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Summary:Highlights • MICAL-L2 is an important regulator of epithelial–mesenchymal transition (EMT) in ovarian cancer. • Silencing of MICAL-L2 inhibited Wnt/β-catenin pathway via preventing nuclear translocation of β-catenin. • MICAL-L2 is up-regulated in ovarian cancer tissues along with FIGO stage and associated with their histologic subgroups. • MICAL-L2 gene maybe a new therapeutic target for interventions against ovarian cancer invasion and metastasis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.04.002