Asarones from Acorus calamus in Combination with Azoles and Amphotericin B: A Novel Synergistic Combination to Compete Against Human Pathogenic Candida Species In Vitro

The increase in drug resistance to current antifungal drugs brings enormous challenges to the management of Candida infection. Therefore, there is a continuous need for the discovery of new antimicrobial agents that are effective against Candida infections especially from natural source especially f...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 2015-04, Vol.175 (8), p.3683-3695
Main Authors: Kumar, S. Nishanth, Aravind, S. R, Sreelekha, T. T, Jacob, Jubi, Kumar, B. S. Dileep
Format: Article
Language:English
Subjects:
Acorus - chemistry
Acorus calamus
amphotericin B
Amphotericin B - administration & dosage
Anisoles - administration & dosage
Anisoles - chemistry
Antifungal Agents
Antimicrobial agents
Azoles - administration & dosage
Biochemistry
biofilm
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Biotechnology
Candida
Candida albicans - drug effects
Candida albicans - pathogenicity
Candidiasis - drug therapy
Candidiasis - microbiology
Chemistry
Chemistry and Materials Science
clotrimazole
Drug resistance
Drug Synergism
drugs
fluconazole
Fungi
Humans
Microbial Sensitivity Tests
minimum inhibitory concentration
Studies
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Summary:The increase in drug resistance to current antifungal drugs brings enormous challenges to the management of Candida infection. Therefore, there is a continuous need for the discovery of new antimicrobial agents that are effective against Candida infections especially from natural source especially from medical plants. The present investigation describes the synergistic anticandidal activity of two asarones (∞ and β) purified from Acorus calamus in combination with three clinically used antifungal drugs (fluconazole, clotrimazole, and amphotericin B). The synergistic anticandidal activities of asarones and drugs were assessed using the checkerboard microdilution and time-kill assays. The results of the present study showed that the combined effects of asarones and drugs principally recorded substantial synergistic activity (fractional inhibitory concentration index (FICI)
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-015-1537-y