Treatments of Generalized Pustular Psoriasis: A Multicenter Study in Japan

This study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy w...

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Bibliographic Details
Published in:Journal of dermatology 1999-03, Vol.26 (3), p.141-149
Main Authors: Ozawa, Akira, Ohkido, Muneo, Haruki, Yasuo, Kobayashi, Hitoshi, Ohkawara, Akira, Ohno, Yoshiyuki, Inaba, Yutaka, Ogawa, Hideoki
Format: Article
Language:English
Subjects:
Adult
cyclosporine
Cyclosporine - adverse effects
Cyclosporine - therapeutic use
Data Collection
Etretinate - adverse effects
Female
generalized pustular psoriasis
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Japan
Male
methotrexate
Methotrexate - adverse effects
Methotrexate - therapeutic use
Middle Aged
Psoriasis - therapy
PUVA
PUVA Therapy - adverse effects
retinoid
Tonsillectomy
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Summary:This study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy with systemic corticosteroid for GPP during only the phase with severe systemic clinical findings may be also effective (75.4%). However, these treatments for GPP each differed in clinical effects, prognosis, and side effects. These findings may be useful in creating guidelines for treatment of generalized pustular psoriasis. Further studies based on these specific clinical effects are necessary.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.1999.tb03444.x