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Treatments of Generalized Pustular Psoriasis: A Multicenter Study in Japan

This study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy w...

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Published in:	Journal of dermatology 1999-03, Vol.26 (3), p.141-149
Main Authors:	Ozawa, Akira, Ohkido, Muneo, Haruki, Yasuo, Kobayashi, Hitoshi, Ohkawara, Akira, Ohno, Yoshiyuki, Inaba, Yutaka, Ogawa, Hideoki
Format:	Article
Language:	English
Subjects:	Adult cyclosporine Cyclosporine - adverse effects Cyclosporine - therapeutic use Data Collection Etretinate - adverse effects Female generalized pustular psoriasis Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Humans Japan Male methotrexate Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Psoriasis - therapy PUVA PUVA Therapy - adverse effects retinoid Tonsillectomy
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container_title	Journal of dermatology
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creator	Ozawa, Akira Ohkido, Muneo Haruki, Yasuo Kobayashi, Hitoshi Ohkawara, Akira Ohno, Yoshiyuki Inaba, Yutaka Ogawa, Hideoki
description	This study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy with systemic corticosteroid for GPP during only the phase with severe systemic clinical findings may be also effective (75.4%). However, these treatments for GPP each differed in clinical effects, prognosis, and side effects. These findings may be useful in creating guidelines for treatment of generalized pustular psoriasis. Further studies based on these specific clinical effects are necessary.
doi_str_mv	10.1111/j.1346-8138.1999.tb03444.x
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Retinoid treatment was effective in 84.1% of patients, methotrexate in 76.2%, cyclosporine in 71.2%, oral PUVA therapy in 45.7%, and tonsillectomy in 16.7%. Short‐term therapy with systemic corticosteroid for GPP during only the phase with severe systemic clinical findings may be also effective (75.4%). However, these treatments for GPP each differed in clinical effects, prognosis, and side effects. These findings may be useful in creating guidelines for treatment of generalized pustular psoriasis. Further studies based on these specific clinical effects are necessary.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/j.1346-8138.1999.tb03444.x</identifier><identifier>PMID: 10209919</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; cyclosporine ; Cyclosporine - adverse effects ; Cyclosporine - therapeutic use ; Data Collection ; Etretinate - adverse effects ; Female ; generalized pustular psoriasis ; Glucocorticoids - adverse effects ; Glucocorticoids - therapeutic use ; Humans ; Japan ; Male ; methotrexate ; Methotrexate - adverse effects ; Methotrexate - therapeutic use ; Middle Aged ; Psoriasis - therapy ; PUVA ; PUVA Therapy - adverse effects ; retinoid ; Tonsillectomy</subject><ispartof>Journal of dermatology, 1999-03, Vol.26 (3), p.141-149</ispartof><rights>1999 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4154-189b7ebe7e48ced4082c845f2b152e82fc8165a20fe2a4d932aca66257bafd2c3</citedby><cites>FETCH-LOGICAL-c4154-189b7ebe7e48ced4082c845f2b152e82fc8165a20fe2a4d932aca66257bafd2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10209919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozawa, Akira</creatorcontrib><creatorcontrib>Ohkido, Muneo</creatorcontrib><creatorcontrib>Haruki, Yasuo</creatorcontrib><creatorcontrib>Kobayashi, Hitoshi</creatorcontrib><creatorcontrib>Ohkawara, Akira</creatorcontrib><creatorcontrib>Ohno, Yoshiyuki</creatorcontrib><creatorcontrib>Inaba, Yutaka</creatorcontrib><creatorcontrib>Ogawa, Hideoki</creatorcontrib><title>Treatments of Generalized Pustular Psoriasis: A Multicenter Study in Japan</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>This study analyzed data from treatments of 385 cases of generalized pustular psoriasis (GPP) from 325 hospitals in Japan. 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subjects	Adult cyclosporine Cyclosporine - adverse effects Cyclosporine - therapeutic use Data Collection Etretinate - adverse effects Female generalized pustular psoriasis Glucocorticoids - adverse effects Glucocorticoids - therapeutic use Humans Japan Male methotrexate Methotrexate - adverse effects Methotrexate - therapeutic use Middle Aged Psoriasis - therapy PUVA PUVA Therapy - adverse effects retinoid Tonsillectomy
title	Treatments of Generalized Pustular Psoriasis: A Multicenter Study in Japan
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