A tailored biocatalyst achieved by the rational anchoring of imidazole groups on a natural polymer: furnishing a potential artificial nuclease by sustainable materials engineering

Foreseeing the development of artificial enzymes by sustainable materials engineering, we rationally anchored reactive imidazole groups on gum arabic, a natural biocompatible polymer. The tailored biocatalyst GAIMZ demonstrated catalytic activity (>10(5)-fold) in dephosphorylation reactions with...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (28), p.6210-6213
Main Authors: Ferreira, José G L, Grein-Iankovski, Aline, Oliveira, Marco A S, Simas-Tosin, Fernanda F, Riegel-Vidotti, Izabel C, Orth, Elisa S
Format: Article
Language:English
Subjects:
Anchoring
Biocatalysis
Biocompatibility
Biocompatible Materials - chemistry
Biocompatible Materials - metabolism
Biocompatible Materials - pharmacology
Catalytic activity
DNA - drug effects
DNA Cleavage
Enzymes
Gum Arabic - chemistry
Gum Arabic - metabolism
Gum Arabic - pharmacology
Imidazole
Imidazoles - chemistry
Materials engineering
Molecular Structure
Nuclease
Phosphorylation
Plasmids
Polymers - chemistry
Polymers - metabolism
Polymers - pharmacology
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Summary:Foreseeing the development of artificial enzymes by sustainable materials engineering, we rationally anchored reactive imidazole groups on gum arabic, a natural biocompatible polymer. The tailored biocatalyst GAIMZ demonstrated catalytic activity (>10(5)-fold) in dephosphorylation reactions with recyclable features and was effective in cleaving plasmid DNA, comprising a potential artificial nuclease.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc00860c