Molecular epidemiology of tuberculosis in Cambodian children

We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian ge...

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Bibliographic Details
Published in:Epidemiology and infection 2015-04, Vol.143 (5), p.910-921
Main Authors: SCHOPFER, K., RIEDER, H. L., STEINLIN-SCHOPFER, J. F., van SOOLINGEN, D., BODMER, T., CHANTANA, Y., STUDER, P., LAURENT, D., ZWAHLEN, M., RICHNER, B.
Format: Article
Language:English
Subjects:
Adolescent
Antitubercular Agents - pharmacology
Cambodia - epidemiology
Child
Child, Preschool
DNA, Bacterial - analysis
Drug Resistance, Multiple, Bacterial - genetics
Epidemiology
Female
Genotype
Genotype & phenotype
Hospitals
Humans
Infant
Infant, Newborn
Isoniazid - pharmacology
Laboratories
Male
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Original Papers
Patients
Pediatrics
Rifampin - pharmacology
Streptomycin - pharmacology
Tuberculosis
Tuberculosis - epidemiology
Tuberculosis - microbiology
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - microbiology
Tuberculosis/mycobacteria
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Summary:We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P 
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268814001769