Molecular imaging of hypoxia in non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) is the commonest cancer worldwide but survival remains poor with a high risk of relapse, particularly after nonsurgical treatment. Hypoxia is present in a variety of solid tumours, including NSCLC. It is associated with treatment resistance and a poor prognosis, al...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2015-05, Vol.42 (6), p.956-976
Main Authors: Yip, Connie, Blower, Philip J., Goh, Vicky, Landau, David B., Cook, Gary J. R.
Format: Article
Language:English
Subjects:
Animals
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - metabolism
Cardiology
Cell Hypoxia
Humans
Hypoxia
Imaging
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - metabolism
Medical imaging
Medicine
Medicine & Public Health
Molecular biology
Nuclear Medicine
Oncology
Orthopedics
Oxygen - metabolism
Positron-Emission Tomography
Radiology
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - pharmacokinetics
Radiopharmaceuticals - pharmacology
Review Article
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Summary:Non-small-cell lung cancer (NSCLC) is the commonest cancer worldwide but survival remains poor with a high risk of relapse, particularly after nonsurgical treatment. Hypoxia is present in a variety of solid tumours, including NSCLC. It is associated with treatment resistance and a poor prognosis, although when recognised may be amenable to different treatment strategies. Thus, noninvasive assessment of intratumoral hypoxia could be used to stratify patients for modification of subsequent treatment to improve tumour control. Molecular imaging approaches targeting hypoxic cells have shown some early success in the clinical setting. This review evaluates the evidence for hypoxia imaging using PET in NSCLC and explores its potential clinical utility.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-015-3009-6