Secondary structure analysis of swine pasivirus (family Picornaviridae) RNA reveals a type-IV IRES and a parechovirus-like 3’ UTR organization

The potential RNA structures of the 5’ and 3’ untranslated regions (UTRs) and cis -acting replication elements (CREs) of a novel pasivirus (PaV) genotype (family Picornaviridae ) were analysed. PaV-A3 (KM259923) was identified in a faecal sample from a domestic pig in Hungary with posterior parapleg...

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Bibliographic Details
Published in:Archives of virology 2015-05, Vol.160 (5), p.1363-1366
Main Authors: Boros, Ákos, Fenyvesi, Hajnalka, Pankovics, Péter, Biró, Hunor, Phan, Tung Gia, Delwart, Eric, Reuter, Gábor
Format: Article
Language:English
Subjects:
3' Untranslated Regions
5' Untranslated Regions
Animals
Annotated Sequence Record
Binding Sites
Biomedical and Life Sciences
Biomedicine
etiology
Evolution, Molecular
feces
Feces - virology
genome
Genomes
genotype
Health care
Hogs
humans
Hungary
Infectious Diseases
Medical Microbiology
Models, Molecular
Molecular Sequence Data
Paralysis
Paraplegia - veterinary
Paraplegia - virology
Parechovirus B
Picornaviridae
Picornaviridae - chemistry
Picornaviridae - genetics
Picornaviridae - isolation & purification
Regions
Ribosomes - metabolism
RNA
RNA Folding
RNA, Viral - chemistry
Sequence Analysis, DNA
Sus scrofa
Swine
Swine Diseases - virology
Virology
Viruses
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Summary:The potential RNA structures of the 5’ and 3’ untranslated regions (UTRs) and cis -acting replication elements (CREs) of a novel pasivirus (PaV) genotype (family Picornaviridae ) were analysed. PaV-A3 (KM259923) was identified in a faecal sample from a domestic pig in Hungary with posterior paraplegia of unknown etiology. Based on likely structural features of the 5’ UTR, the pasiviruses were inferred to possess Hepacivirus / Pestivirus -like type-IV IRES. The pasivirus CRE was mapped to the 2B genome region, similar to Ljungan virus. The secondary RNA structure of the pasivirus 3’ UTR was structurally similar to that of human parechoviruses. The genome, CRE, and 3’ UTR of pasiviruses provide further evidence of the common origin of the members of the genera Parechovirus and Pasivirus, although their different 5’ UTR IRES types suggest that a recombination event occurred during the divergence these viruses.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-015-2371-9