Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp. F9A015

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectrosc...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2015-03, Vol.78 (3), p.363-367
Main Authors: Kim, Hiyoung, Yang, Inho, Ryu, Shin-Young, Won, Dong Hwan, Giri, Awadut G, Wang, Weihong, Choi, Hyukjae, Chin, Jungwook, Hahn, Dongyup, Kim, Eunhee, Han, Chulkyeong, Lee, Jihye, Nam, Sang-Jip, Ho, Won-Kyung, Kang, Heonjoong
Format: Article
Language:English
Subjects:
Acremonium
Acremonium - chemistry
Animals
Benzophenones - chemistry
Benzophenones - isolation & purification
Benzophenones - pharmacology
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Insulin - metabolism
Insulin Secretion
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera - microbiology
Potassium Channel Blockers - chemistry
Potassium Channel Blockers - isolation & purification
Potassium Channel Blockers - pharmacology
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Summary:Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.
ISSN:0163-3864
1520-6025
DOI:10.1021/np5007586