The 39-kilodalton outer membrane protein of Proteus mirabilis is an OmpA protein and mitogen for murine B lymphocytes

Partial amino acid sequence analysis of a major outer membrane protein of Proteus mirabilis (39-kDa protein) indicates that it is an OmpA protein. The mitogenic activities of the 39-kDa protein for murine lymphocytes were also investigated with T lymphocytes isolated by passing spleen cells over col...

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Bibliographic Details
Published in:Infection and immunity 1993-01, Vol.61 (11), p.4933-4936
Main Authors: Korn, A, Kroll, H-P, Berger, H-P, Kahler, A, Hessler, R, Brauburger, J, Mueller, K-P, Nixdorff, K
Format: Article
Language:English
Subjects:
Proteus mirabilis
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Summary:Partial amino acid sequence analysis of a major outer membrane protein of Proteus mirabilis (39-kDa protein) indicates that it is an OmpA protein. The mitogenic activities of the 39-kDa protein for murine lymphocytes were also investigated with T lymphocytes isolated by passing spleen cells over columns of nylon wool fiber and B lymphocytes obtained by treating spleen cells with monoclonal antibodies to Thy1 plus complement. The 39-kDa protein showed little activity in stimulating T cells to proliferate but was strongly mitogenic for B cells.
ISSN:0019-9567