The synaptic vesicle cycle: a cascade of protein-protein interactions

The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergen...

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Bibliographic Details
Published in:Nature (London) 1995-06, Vol.375 (6533), p.645-653
Main Author: Sudhof, Thomas C
Format: Article
Language:English
Subjects:
Animals
Bacterial Toxins - pharmacology
Biological and medical sciences
Brain
Calcium-Binding Proteins
Endocytosis
Exocytosis
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
GTP-Binding Proteins - physiology
Humanities and Social Sciences
Humans
Membrane Fusion
Membrane Glycoproteins - physiology
Molecular biology
multidisciplinary
Nerve Tissue Proteins - physiology
Neurology
Neuronal Plasticity
Neurons
Proteins
rab3 GTP-Binding Proteins
review-article
Science
Science (multidisciplinary)
Synaptic Vesicles - drug effects
Synaptic Vesicles - physiology
Synaptotagmins
Vertebrates: nervous system and sense organs
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Summary:The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all cellular transport pathways, the synaptic vesicle cycle is the fastest and the most tightly regulated. A convergence of results now allows formulation of molecular models for key steps of the cycle. These developments may form the basis for a mechanistic understanding of higher neural function.
ISSN:0028-0836
1476-4687
DOI:10.1038/375645a0