The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions

Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occur...

Full description

Saved in:
Bibliographic Details
Published in:Heart and vessels 2015-05, Vol.30 (3), p.379-385
Main Authors: Min, Too Jae, Jo, Won-Min, Shin, Seung Yong, Lim, Hong Euy
Format: Article
Language:English
Subjects:
Animals
Atrial Fibrillation - etiology
Atrial Fibrillation - metabolism
Atrial Fibrillation - physiopathology
Atrial Fibrillation - prevention & control
Biomedical Engineering and Bioengineering
Cardiac arrhythmia
Cardiac Pacing, Artificial
Cardiac Surgery
Cardiology
Cardiomyopathies - complications
Cardiomyopathies - metabolism
Cardiomyopathies - physiopathology
Coronary Circulation
Disease Models, Animal
Heart Atria - metabolism
Heart Atria - physiopathology
Heat shock proteins
HSP70 Heat-Shock Proteins - metabolism
Isolated Heart Preparation
Male
Medicine
Medicine & Public Health
Original Article
Rats, Sprague-Dawley
Rodents
Signal Transduction
Time Factors
Up-Regulation
Vascular Surgery
Ventricular Function, Left
Ventricular Pressure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague–Dawley rats: an ischemic CM group ( n  = 12), a non-ischemic dilated CM group ( n  = 12), a pressure-overload hypertrophic CM group ( n  = 12), and a sham group (CON, n  = 12). After 4–6 weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups ( P  
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-014-0521-8