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The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions
Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occur...
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| Published in: | Heart and vessels 2015-05, Vol.30 (3), p.379-385 |
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| creator | Min, Too Jae Jo, Won-Min Shin, Seung Yong Lim, Hong Euy |
| description | Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague–Dawley rats: an ischemic CM group (
n
= 12), a non-ischemic dilated CM group (
n
= 12), a pressure-overload hypertrophic CM group (
n
= 12), and a sham group (CON,
n
= 12). After 4–6 weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups (
P
|
| doi_str_mv | 10.1007/s00380-014-0521-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680748607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1680748607</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-a81ea09207867ac289ecccdc6153d3dff7ed73c5632478ca53caf5887bf5f183</originalsourceid><addsrcrecordid>eNp1kUtPAyEUhYnR2Pr4AW4MiZu6GL3ADDBL0_hKTNx0TygDltoOFaYm_fcyjhpj4ooL97vnHnIQOiNwRQDEdQJgEgogZQEVJYXcQ2PCSVXQSrB9NIaaQCEZFSN0lNISgFQ1qQ_RiJayBsbpGMXZwuJNDJ01nX-32DqXKxwcXljd4bQI5nXo-xYLwJOHtBFwifNNd9HrFXZ-Hv1qpTsf2v75XUcftgkbHRsf1ruw0d1ih01oG98z6QQdOL1K9vTrPEazu9vZ9KF4er5_nN48FabkvCu0JFZDTUFILrShsrbGmMbk_7GGNc4J2whmKs5oKaTRFTPaVVKKuasckewYTQbZ7P5ta1On1j4Zm522NvtThEsQpeQgMnrxB12GbWyzuU8K6ho4yxQZKBNDStE6tYl-reNOEVB9HmrIQ-U8VJ-H6k2cfylv52vb_Ex8B5ABOgApt9oXG3-t_lf1AwY-lcs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1680099063</pqid></control><display><type>article</type><title>The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions</title><source>Springer Nature</source><creator>Min, Too Jae ; Jo, Won-Min ; Shin, Seung Yong ; Lim, Hong Euy</creator><creatorcontrib>Min, Too Jae ; Jo, Won-Min ; Shin, Seung Yong ; Lim, Hong Euy</creatorcontrib><description>Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague–Dawley rats: an ischemic CM group (
n
= 12), a non-ischemic dilated CM group (
n
= 12), a pressure-overload hypertrophic CM group (
n
= 12), and a sham group (CON,
n
= 12). After 4–6 weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups (
P
< 0.005). Among these CM groups, the TAC group revealed lower Hsp70 levels and higher induction rates of atrial fibrillation than the other groups (
P
< 0.005). The level of Hsp70 was elevated in all the CM models and it was negatively correlated with AF induction rate in sham group. However, we could not find correlation between Hsp70 and AF among the CM models.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/s00380-014-0521-8</identifier><identifier>PMID: 24890362</identifier><identifier>CODEN: HEVEEO</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Atrial Fibrillation - etiology ; Atrial Fibrillation - metabolism ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - prevention & control ; Biomedical Engineering and Bioengineering ; Cardiac arrhythmia ; Cardiac Pacing, Artificial ; Cardiac Surgery ; Cardiology ; Cardiomyopathies - complications ; Cardiomyopathies - metabolism ; Cardiomyopathies - physiopathology ; Coronary Circulation ; Disease Models, Animal ; Heart Atria - metabolism ; Heart Atria - physiopathology ; Heat shock proteins ; HSP70 Heat-Shock Proteins - metabolism ; Isolated Heart Preparation ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Rats, Sprague-Dawley ; Rodents ; Signal Transduction ; Time Factors ; Up-Regulation ; Vascular Surgery ; Ventricular Function, Left ; Ventricular Pressure</subject><ispartof>Heart and vessels, 2015-05, Vol.30 (3), p.379-385</ispartof><rights>Springer Japan 2014</rights><rights>Springer Japan 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-a81ea09207867ac289ecccdc6153d3dff7ed73c5632478ca53caf5887bf5f183</citedby><cites>FETCH-LOGICAL-c466t-a81ea09207867ac289ecccdc6153d3dff7ed73c5632478ca53caf5887bf5f183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24890362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Min, Too Jae</creatorcontrib><creatorcontrib>Jo, Won-Min</creatorcontrib><creatorcontrib>Shin, Seung Yong</creatorcontrib><creatorcontrib>Lim, Hong Euy</creatorcontrib><title>The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><addtitle>Heart Vessels</addtitle><description>Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague–Dawley rats: an ischemic CM group (
n
= 12), a non-ischemic dilated CM group (
n
= 12), a pressure-overload hypertrophic CM group (
n
= 12), and a sham group (CON,
n
= 12). After 4–6 weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups (
P
< 0.005). Among these CM groups, the TAC group revealed lower Hsp70 levels and higher induction rates of atrial fibrillation than the other groups (
P
< 0.005). The level of Hsp70 was elevated in all the CM models and it was negatively correlated with AF induction rate in sham group. However, we could not find correlation between Hsp70 and AF among the CM models.</description><subject>Animals</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - metabolism</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - metabolism</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Coronary Circulation</subject><subject>Disease Models, Animal</subject><subject>Heart Atria - metabolism</subject><subject>Heart Atria - physiopathology</subject><subject>Heat shock proteins</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Isolated Heart Preparation</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Signal Transduction</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><subject>Vascular Surgery</subject><subject>Ventricular Function, Left</subject><subject>Ventricular Pressure</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kUtPAyEUhYnR2Pr4AW4MiZu6GL3ADDBL0_hKTNx0TygDltoOFaYm_fcyjhpj4ooL97vnHnIQOiNwRQDEdQJgEgogZQEVJYXcQ2PCSVXQSrB9NIaaQCEZFSN0lNISgFQ1qQ_RiJayBsbpGMXZwuJNDJ01nX-32DqXKxwcXljd4bQI5nXo-xYLwJOHtBFwifNNd9HrFXZ-Hv1qpTsf2v75XUcftgkbHRsf1ruw0d1ih01oG98z6QQdOL1K9vTrPEazu9vZ9KF4er5_nN48FabkvCu0JFZDTUFILrShsrbGmMbk_7GGNc4J2whmKs5oKaTRFTPaVVKKuasckewYTQbZ7P5ta1On1j4Zm522NvtThEsQpeQgMnrxB12GbWyzuU8K6ho4yxQZKBNDStE6tYl-reNOEVB9HmrIQ-U8VJ-H6k2cfylv52vb_Ex8B5ABOgApt9oXG3-t_lf1AwY-lcs</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Min, Too Jae</creator><creator>Jo, Won-Min</creator><creator>Shin, Seung Yong</creator><creator>Lim, Hong Euy</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions</title><author>Min, Too Jae ; Jo, Won-Min ; Shin, Seung Yong ; Lim, Hong Euy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-a81ea09207867ac289ecccdc6153d3dff7ed73c5632478ca53caf5887bf5f183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - metabolism</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - metabolism</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Coronary Circulation</topic><topic>Disease Models, Animal</topic><topic>Heart Atria - metabolism</topic><topic>Heart Atria - physiopathology</topic><topic>Heat shock proteins</topic><topic>HSP70 Heat-Shock Proteins - metabolism</topic><topic>Isolated Heart Preparation</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Signal Transduction</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><topic>Vascular Surgery</topic><topic>Ventricular Function, Left</topic><topic>Ventricular Pressure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Min, Too Jae</creatorcontrib><creatorcontrib>Jo, Won-Min</creatorcontrib><creatorcontrib>Shin, Seung Yong</creatorcontrib><creatorcontrib>Lim, Hong Euy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Min, Too Jae</au><au>Jo, Won-Min</au><au>Shin, Seung Yong</au><au>Lim, Hong Euy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions</atitle><jtitle>Heart and vessels</jtitle><stitle>Heart Vessels</stitle><addtitle>Heart Vessels</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>30</volume><issue>3</issue><spage>379</spage><epage>385</epage><pages>379-385</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><coden>HEVEEO</coden><abstract>Heat shock proteins (Hsp) protect myocardial cells from acute stress such as atrial fibrillation (AF) and also from the chronic stress. It is not understood that Hsp70 can prevent AF under cardiomyopathy (CM) conditions. Therefore, we hypothesized that Hsp70 might beneficially influence on the occurrence of AF in CM conditions. We purposed to investigate the correlation between Hsp70 and the AF inducibility in various CM conditions that are unclear. We constructed four different animal models using Sprague–Dawley rats: an ischemic CM group (
n
= 12), a non-ischemic dilated CM group (
n
= 12), a pressure-overload hypertrophic CM group (
n
= 12), and a sham group (CON,
n
= 12). After 4–6 weeks of intervention animals, AF was induced acutely prior to hemodynamic studies. Hemodynamic data using the Langendorff technique and histologic evaluation were conducted sequentially in all animal groups. Afterwards, levels of Hsp70 were measured from atrial tissues by real-time polymerase chain reaction study. The hemodynamic data and histologic studies proved that each animal model was suitable to this study protocol. All CM groups showed that Hsp70 was elevated significantly compared to the control groups (
P
< 0.005). Among these CM groups, the TAC group revealed lower Hsp70 levels and higher induction rates of atrial fibrillation than the other groups (
P
< 0.005). The level of Hsp70 was elevated in all the CM models and it was negatively correlated with AF induction rate in sham group. However, we could not find correlation between Hsp70 and AF among the CM models.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24890362</pmid><doi>10.1007/s00380-014-0521-8</doi><tpages>7</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Animals Atrial Fibrillation - etiology Atrial Fibrillation - metabolism Atrial Fibrillation - physiopathology Atrial Fibrillation - prevention & control Biomedical Engineering and Bioengineering Cardiac arrhythmia Cardiac Pacing, Artificial Cardiac Surgery Cardiology Cardiomyopathies - complications Cardiomyopathies - metabolism Cardiomyopathies - physiopathology Coronary Circulation Disease Models, Animal Heart Atria - metabolism Heart Atria - physiopathology Heat shock proteins HSP70 Heat-Shock Proteins - metabolism Isolated Heart Preparation Male Medicine Medicine & Public Health Original Article Rats, Sprague-Dawley Rodents Signal Transduction Time Factors Up-Regulation Vascular Surgery Ventricular Function, Left Ventricular Pressure |
| title | The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions |
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