Expression of cadherin 17 in well-differentiated neuroendocrine tumours

Aims Cadherin 17 (CDH17) is expressed primarily in normal intestinal epithelium and digestive tract tumours, and has limited expression in other neoplasms. The aims of this study were to examine CDH17 expression in well‐differentiated neuroendocrine tumours (WDNETs) from various primary sites, repre...

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Bibliographic Details
Published in:Histopathology 2015-06, Vol.66 (7), p.1010-1021
Main Authors: Snow, Anthony N, Mangray, Shamlal, Lu, Shaolei, Clubwala, Rashna, Li, Jianhong, Resnick, Murray B, Yakirevich, Evgeny
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
cadherin17
Cadherins - metabolism
CDH17
CDX2
DNA-Binding Proteins - metabolism
Humans
Immunohistochemistry
Intestinal Neoplasms - metabolism
Intestinal Neoplasms - pathology
Male
Neuroendocrine Tumors - metabolism
Neuroendocrine Tumors - pathology
neuroendocrine tumour
Transcription Factors
TTF1
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Summary:Aims Cadherin 17 (CDH17) is expressed primarily in normal intestinal epithelium and digestive tract tumours, and has limited expression in other neoplasms. The aims of this study were to examine CDH17 expression in well‐differentiated neuroendocrine tumours (WDNETs) from various primary sites, representing the foregut, midgut, and hindgut, and tumours metastasizing to the liver, and to correlate the differences between the expression of CDH17, CDX2, and thyroid transcription factor 1 (TTF1). Methods and results We investigated CDH17 immunohistochemical expression in 150 primary WDNETs from eight anatomical sites, including 68 from the foregut, 70 from the midgut, and 12 from the hindgut, and 15 metastases. CDH17 immunoreactivity increased significantly from foregut to hindgut WDNETs (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12610