Role of IL-6 −174(G/C) promoter polymorphism in the etiology of early-onset preeclampsia

• Published in: Inflammation research 2015-06, Vol.64 (6), p.433-439
• Main Authors: Sowmya, Sabnavis, Ramaiah, Aruna, Nallari, Pratibha, Jyothy, Akka, Venkateshwari, Ananthapur
• Format: Article
• Language: English
• Subjects: Adult; Aging - physiology; Alleles; Allergology; Biomedical and Life Sciences; Biomedicine; Case-Control Studies; Dermatology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Immunology; Interleukin-6 - genetics; Neurology; Original Research Paper; Pharmacology/Toxicology; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Pre-Eclampsia - epidemiology; Pre-Eclampsia - genetics; Pregnancy; Promoter Regions, Genetic - genetics; Rheumatology
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-015-0823-z

Objective To investigate the relationship between IL-6 −174G/C promoter polymorphism and preeclampsia. Methods A total of 140 preeclamptic women and 135 women with normal pregnancy were considered for the present study. A standard amplification refractory mutation system PCR was carried out for genotyping of IL-6 G−174C promoter polymorphism. Genotypic distribution was compared with values predicted by Hardy–Weinberg equilibrium using χ 2 test. Odds ratios and their respective 95 % confidence intervals were used to measure the strength of association. Results The frequencies observed, CC, GC and GG, were 53.5, 26.6 and 20 % in patients and 26.6, 23.7 and 49.6 % in the controls. There is a significant difference in the distribution of genotypes and alleles of IL-6 G−174 C between the two groups. Conclusion The present study suggests that the IL-6 −174 promoter polymorphism is a major genetic regulator in the etiology of early-onset preeclampsia.