Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures

Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neuron...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 1995-06, Vol.30 (2), p.327-335
Main Authors: Donovan, David M., Vandenbergh, David J., Perry, Michael P., Bird, Geoffrey S., Ingersoll, Roxann, Nanthakumar, Elizabeth, Uhl, George R.
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biochemistry and metabolism
Biological and medical sciences
Blotting, Northern
Carrier Proteins - chemistry
Carrier Proteins - genetics
Central nervous system
Cocaine
DNA, Complementary
Dopamine - chemistry
Dopamine - genetics
Dopamine - metabolism
Dopamine Plasma Membrane Transport Proteins
Fundamental and applied biological sciences. Psychology
Gene
Gene Expression - genetics
Humans
Membrane Glycoproteins
Membrane Transport Proteins
Mice
Molecular Sequence Data
Nerve Tissue Proteins
Parkinson's disease
Polymerase Chain Reaction
Promoter
Promoter Regions, Genetic - genetics
RNA, Messenger - metabolism
Transporter
Vertebrates: nervous system and sense organs
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Summary:Synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (DAT), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. Several DAT features, including its exclusive expression in dopaminergic neurons, implication in cocaine action, and prominent role in the mechanisms of Parkinsonism-inducing neurotoxins, make understanding of the DAT gene of interest. Isolation and characterization of the human and mouse DAT genes has allowed elucidation of similarities between each and other members of this transporter gene family. Sequences 5′ to transcriptional start sites contain G-C rich, TATA-less, CAAT-less regions with striking conservation between human and mouse gene flanking regions. These studies suggest sequence elements that are candidates to contribute to the dopamine transporter's dopaminergic cell-specific expression.
ISSN:0169-328X
1872-6941
DOI:10.1016/0169-328X(95)00018-N