m-Chlorophenylpiperazine decreases food intake in a test meal

We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused si...

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Bibliographic Details
Published in:Psychopharmacologia 1994-09, Vol.116 (1), p.120-122
Main Authors: WALSH, A. E. S, SMITH, K. A, OLDMAN, A. D, WILLIAMS, C, GOODALL, E. M, COWEN, P. J
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Depression, Chemical
Double-Blind Method
Eating - drug effects
Female
General and cellular metabolism. Vitamins
Humans
Hunger - drug effects
Medical sciences
Pharmacology. Drug treatments
Piperazines - adverse effects
Piperazines - pharmacology
Serotonin Receptor Agonists - adverse effects
Serotonin Receptor Agonists - pharmacology
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Summary:We studied the effect of the 5-HT receptor agonist, m-chlorophenylpiperazine (mCPP) (0.4 mg/kg), on food intake in 12 healthy female volunteers, in a double-blind placebo controlled design. Compared to placebo, mCPP significantly lowered food intake in a test meal. Treatment with mCPP also caused significant increases in ratings of nausea and light-headedness, though these effects had remitted by the time of the test meal. The results suggest that activation of brain 5-HT2C receptors may lower food intake in humans; it is also possible, however, that the hypophagic effect of mCPP in the present study could be a consequence of its adverse subjective side effects.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02244883