Metabolism of the polycyclic aromatic hydrocarbon pyrene by Aspergillus niger SK 9317

The metabolism of pyrene, a polycyclic aromatic hydrocarbon consisting of four rings, by Aspergillus niger SK 9317 was investigated. The metabolites formed were isolated and identified as 1-hydroxypyrene, 1,6- and 1,8-pyrenequinone, 1,6- and 1,8-dihydroxypyrene, 1-pyrenyl sulphate and 1-hydroxy-8-py...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 1994-12, Vol.42 (4), p.636-641
Main Authors: Wunder, T, Kremer, S, Sterner, O, Anke, H
Format: Article
Language:English
Subjects:
aromatic hydrocarbons
Aspergillus nidulans
Aspergillus niger
Aspergillus niger - metabolism
Biodegradation, Environmental
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Cytochrome P-450 Enzyme System - metabolism
Environmental Pollutants - metabolism
Fermentation
Fundamental and applied biological sciences. Psychology
Hydroxylation
metabolism
Mission oriented research
Models, Chemical
Molecular Structure
Oxygenases - metabolism
Physiology and metabolism
polycyclic hydrocarbons
Pyrenes - chemistry
Pyrenes - metabolism
Quinones - metabolism
soil fungi
Sulfates - metabolism
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Summary:The metabolism of pyrene, a polycyclic aromatic hydrocarbon consisting of four rings, by Aspergillus niger SK 9317 was investigated. The metabolites formed were isolated and identified as 1-hydroxypyrene, 1,6- and 1,8-pyrenequinone, 1,6- and 1,8-dihydroxypyrene, 1-pyrenyl sulphate and 1-hydroxy-8-pyrenyl sulphate. This is the first report of 1-hydroxy-8-pyrenyl as a metabolite in the microbial metabolism of pyrene. The results suggest that A. niger metabolizes pyrene by cytochrome P450 monooxygenase enzyme systems.
ISSN:0175-7598
1432-0614
DOI:10.1007/bf00173932