Afferent synaptic changes in auditory hair cells during noise-induced temporary threshold shift

This study presents evidence in support of the hypothesis that one of the sites of failure during noise-induced temporary threshold shift (TTS) is the afferent synapse between auditory hair cells and auditory nerve fibers. Our results show clear evidence indicating changes in the quantity of afferen...

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Bibliographic Details
Published in:Hearing research 1995-04, Vol.84 (1), p.81-90
Main Authors: Henry, William R., Mulroy, Michael J.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Alligator lizard
Anguidae
Animals
Auditory Threshold - physiology
Basilar Membrane - physiology
Biological and medical sciences
Cochlea
Cochlea - physiology
Disease Models, Animal
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Fundamental and applied biological sciences. Psychology
Gerrhonotus
Hair cell
Hair Cells, Auditory - cytology
Hair Cells, Auditory - ultrastructure
Hearing Loss, Noise-Induced - etiology
Image Processing, Computer-Assisted
Lizards
Microscopy, Electron
Microscopy, Electron, Scanning
Nerve Fibers - physiology
Neurons, Afferent - cytology
Neurons, Afferent - physiology
Neurons, Afferent - ultrastructure
Noise-induced hearing loss
Presynaptic Terminals - physiology
Synapse
Synapses - physiology
Synapses - ultrastructure
Synaptic body
Synaptic Vesicles - physiology
TTS
Vertebrates: nervous system and sense organs
Vestibulocochlear Nerve - physiology
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Description
Summary:This study presents evidence in support of the hypothesis that one of the sites of failure during noise-induced temporary threshold shift (TTS) is the afferent synapse between auditory hair cells and auditory nerve fibers. Our results show clear evidence indicating changes in the quantity of afferent synapses and the morphology of presynaptic structures in the alligator lizard auditory hair cells during TTS. In TTS hair cells there are statistically significant decreases in: 1) the number of afferent synapses, 2) the number of synaptic vesicles at the afferent synapses, 3) the size of synaptic bodies, and 4) the packing density of synaptic vesicles around the synaptic body. These results suggest that the presynaptic components of the afferent synapse reflect the functional state of the synapse, and that the reduction of these synapses, both in number and component size, contributes to TTS.
ISSN:0378-5955
1878-5891
DOI:10.1016/0378-5955(95)00014-U