The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children

Abstract Very preterm children are at a high risk for neurodevelopmental impairments, but there is variability in the pattern and severity of outcome. Neonatal magnetic resonance imaging (MRI) enhances the capacity to detect brain injury and altered brain development and assists in the prediction of...

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Bibliographic Details
Published in:Seminars in perinatology 2015-03, Vol.39 (2), p.147-158
Main Authors: Anderson, Peter J., PhD, Cheong, Jeanie L.Y., MD, Thompson, Deanne K., PhD
Format: Article
Language:English
Subjects:
Brain - growth & development
Brain - pathology
Brain Injuries - diagnosis
Brain Injuries - physiopathology
Developmental Disabilities - diagnosis
Developmental Disabilities - physiopathology
diffusion weight imaging
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - diagnosis
Infant, Premature, Diseases - physiopathology
Intensive Care, Neonatal
Magnetic Resonance Imaging
Neonatal and Perinatal Medicine
neurodevelopmental outcome
Neuroimaging - methods
Predictive Value of Tests
Severity of Illness Index
very preterm
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Summary:Abstract Very preterm children are at a high risk for neurodevelopmental impairments, but there is variability in the pattern and severity of outcome. Neonatal magnetic resonance imaging (MRI) enhances the capacity to detect brain injury and altered brain development and assists in the prediction of high-risk children who warrant surveillance and early intervention. This review describes the application of conventional and advanced MRI with very preterm neonates, specifically focusing on the relationship between neonatal MRI findings and later neurodevelopmental outcome. Research demonstrates that conventional MRI is strongly associated with neurodevelopmental outcome in childhood. Further studies are needed to examine the role of advanced MRI techniques in predicting outcome in very preterm children, but early research findings are promising. In conclusion, neonatal MRI is predictive of later neurodevelopment but is dependent on appropriately trained specialists and should be interpreted in conjunction with other clinical and social information.
ISSN:0146-0005
1558-075X
DOI:10.1053/j.semperi.2015.01.008