Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer

• Published in: Food chemistry 2015-11, Vol.186, p.13-19
• Main Authors: Wang, Tuoyi, Li, Chunyan, Liu, Yang, Li, Tiezhu, Zhang, Jie, Sun, Yonghai
• Format: Article
• Language: English
• Subjects: Aflatoxin B1 - chemistry; Animals; Anticarcinogenic Agents - chemistry; Brassica - adverse effects; Diet; DNA Adducts - chemistry; Female; Liver - drug effects; Liver Neoplasms - chemically induced; Liver Neoplasms - drug therapy; Liver Neoplasms - prevention & control; Male; Mice; Mice, Inbred BALB C; Plant Extracts - chemistry; Temperature; Water
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2015.02.138

In this study, 0.25 μg/ml aflatoxin B1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 °C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms.