Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease

• Published in: Neurobiology of aging 2015-06, Vol.36 (6), p.2018-2023
• Main Authors: Alcolea, Daniel, Vilaplana, Eduard, Pegueroles, Jordi, Montal, Victor, Sánchez-Juan, Pascual, González-Suárez, Andrea, Pozueta, Ana, Rodríguez-Rodríguez, Eloy, Bartrés-Faz, David, Vidal-Piñeiro, Dídac, González-Ortiz, Sofía, Medrano, Santiago, Carmona-Iragui, María, Sánchez-Saudinós, M Belén, Sala, Isabel, Anton-Aguirre, Sofía, Sampedro, Frederic, Morenas-Rodríguez, Estrella, Clarimón, Jordi, Blesa, Rafael, Lleó, Alberto, Fortea, Juan
• Format: Article
• Language: English
• Subjects: Adipokines - cerebrospinal fluid; Aged; Alzheimer Disease - diagnosis; Alzheimer Disease - pathology; Atrophy; Biomarkers - cerebrospinal fluid; Cerebral Cortex - pathology; Chitinase-3-Like Protein 1; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - pathology; Cortical thickness; CSF biomarkers; Female; Humans; Inflammation; Internal Medicine; Lectins - cerebrospinal fluid; Magnetic Resonance Imaging; Male; Middle Aged; Neuroinflammation; Neurology; Preclinical Alzheimer's disease; Structural MRI; tau Proteins - cerebrospinal fluid; YKL-40
• ISSN: 0197-4580; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2015.03.001

Abstract Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1–42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.