Annexin A2 plays a critical role in epithelial ovarian cancer

Purpose This study aimed at investigating the potential role and prognostic significance of Annexin A2 in human epithelial ovarian cancer (EOC). Methods Western blot was used to evaluate the expression of Annexin A2 in nine fresh EOC tissues, and immunohistochemical analysis was performed on formali...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2015-07, Vol.292 (1), p.175-182
Main Authors: Deng, Yan, Chen, Chen, Hua, Minhui, Xi, Qinghua, Liu, Rong, Yang, Shuyun, Liu, Jian, Zhong, Jianxin, Tang, Meilan, Lu, Shumin, Tang, Chunhui, Wang, Yingying
Format: Article
Language:English
Subjects:
Adult
Aged
Annexin A2 - metabolism
Carcinoma, Ovarian Epithelial
Cell cycle
Cell growth
Cell Proliferation - physiology
Disease Progression
Endocrinology
Female
Gynecologic Oncology
Gynecology
Human Genetics
Humans
Kaplan-Meier Estimate
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasms, Glandular and Epithelial - pathology
Obstetrics/Perinatology/Midwifery
Ovarian cancer
Ovarian Neoplasms - pathology
Prognosis
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Summary:Purpose This study aimed at investigating the potential role and prognostic significance of Annexin A2 in human epithelial ovarian cancer (EOC). Methods Western blot was used to evaluate the expression of Annexin A2 in nine fresh EOC tissues, and immunohistochemical analysis was performed on formalin-fixed paraffin-embedded sections of 119 cases of ovarian cancers. Then, we used Fisher exact test to analyze the correlation between Annexin A2 and clinicopathological parameters. Starvation refeeding was used to detect the alteration of Annexin A2 in HO8910 cell cycle. Results Annexin A2 was overexpressed in carcinoma tissues compared with normal tissue, and the expression levels gradually increased from G1 to G3. Moreover, the staining of tissue microarray was consistent with the result we got from western blot, increasing from G1 to G3 gradually, and it was related to the Figo stage ( P  = 0.005), histologic grade ( P  = 0.002), ascite ( P  
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-014-3598-5