Combined Papillary and Mucoepidermoid Carcinoma of the Thyroid Gland: a Possible Collision Tumor Diagnosed on Fine-Needle Cytology. Report of a Case with Immunocytochemical and Molecular Correlations

Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly ide...

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Bibliographic Details
Published in:Endocrine pathology 2015-05, Vol.26 (2), p.140-144
Main Authors: Fulciniti, Franco, Vuttariello, Emilia, Calise, Celeste, Monaco, Mario, Pezzullo, Luciano, Chiofalo, Maria Grazia, Di Gennaro, Francesca, Malzone, Maria Gabriella, Campanile, Anna Cipolletta, Losito, Nunzia Simona, Botti, Gerardo, Chiappetta, Gennaro
Format: Article
Language:English
Subjects:
Adult
Biopsy, Fine-Needle
Carcinoma - diagnosis
Carcinoma - metabolism
Carcinoma - pathology
Carcinoma, Mucoepidermoid - diagnosis
Carcinoma, Mucoepidermoid - metabolism
Carcinoma, Mucoepidermoid - pathology
Carcinoma, Papillary
Diagnosis, Differential
Endocrinology
Female
Humans
Immunohistochemistry
Medicine
Medicine & Public Health
Mixed Tumor, Malignant - diagnosis
Mixed Tumor, Malignant - metabolism
Mixed Tumor, Malignant - pathology
Molecular Diagnostic Techniques
Oncology
Pathology
Thyroid Cancer, Papillary
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
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Summary:Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly identified on FNC. The papillary component had a classic immunophenotype (CK19+, TTF1+), while the mucoepidermoid one was only focally CK19+. Point mutations ( BRAF and RAS ) and rearrangements ( RET /PTC) of the papillary component have been also investigated on FNC samples, with resulting concurrent rearrangements of RET/ PTC1 and RET/ PTC3, but no point mutations. The histogenesis of combined papillary and mucoepidermoid carcinoma of the thyroid still remains partly unsettled, and further genomic studies are needed to shed some more light on this peculiar neoplasm.
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-015-9364-9