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Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population
Objective To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10. Methods Ethnically Han Chinese patients with migraine and...
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| Published in: | Journal of international medical research 2015-06, Vol.43 (3), p.326-331 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c445t-7bb11acf0d83b00884ede2a6f24826053908d2aa042647d4b4c6f37f6928528d3 |
| container_end_page | 331 |
| container_issue | 3 |
| container_start_page | 326 |
| container_title | Journal of international medical research |
| container_volume | 43 |
| creator | Jia, Shasha Dong, Wanli Zhou, Xianju Chen, Zhiguo Yun, Wenwei |
| description | Objective
To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
Methods
Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
Results
Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
Conclusion
There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis. |
| doi_str_mv | 10.1177/0300060514565681 |
| format | article |
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To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
Methods
Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
Results
Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
Conclusion
There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060514565681</identifier><identifier>PMID: 25712717</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Asian Continental Ancestry Group - genetics ; China ; Ethnic Groups - genetics ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Middle Aged ; Migraine Disorders - epidemiology ; Migraine Disorders - genetics ; Polymorphism, Single Nucleotide - genetics ; TNF-Related Apoptosis-Inducing Ligand - genetics ; Young Adult</subject><ispartof>Journal of international medical research, 2015-06, Vol.43 (3), p.326-331</ispartof><rights>The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-7bb11acf0d83b00884ede2a6f24826053908d2aa042647d4b4c6f37f6928528d3</citedby><cites>FETCH-LOGICAL-c445t-7bb11acf0d83b00884ede2a6f24826053908d2aa042647d4b4c6f37f6928528d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0300060514565681$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0300060514565681$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25712717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Shasha</creatorcontrib><creatorcontrib>Dong, Wanli</creatorcontrib><creatorcontrib>Zhou, Xianju</creatorcontrib><creatorcontrib>Chen, Zhiguo</creatorcontrib><creatorcontrib>Yun, Wenwei</creatorcontrib><title>Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objective
To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
Methods
Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
Results
Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
Conclusion
There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>China</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Migraine Disorders - epidemiology</subject><subject>Migraine Disorders - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>TNF-Related Apoptosis-Inducing Ligand - genetics</subject><subject>Young Adult</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp1kMFLwzAYxYMobk7vniRHL9UvaZpkxzGcCkMPzptQ0jbdMtqmJi1j_72pmx4ET4G893687yF0TeCOECHuIQYADglhCU-4JCdoTJiIIxr-T9F4kKNBH6EL77cAjPKEnqMRTQShgogx-ph5b3OjOmMbnOlup3WDVy-LtwUB3NpqX1vXboyvsWoKXJu1U6bR2Pc-121nMlOZbo9NgxWeb4LidUi1ffUNvERnpaq8vjq-E_S-eFjNn6Ll6-PzfLaMcsaSLhJZRojKSyhknAFIyXShqeIlZZKG9vEUZEGVGuozUbCM5byMRcmnVCZUFvEE3R64rbOfvfZdWpvQr6pUo23vU8IlpcCJFMEKB2vurPdOl2nrTK3cPiWQDpumfzcNkZsjvc9qXfwGfkYMhuhg8Gqt063tXROu_R_4BUpCfac</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Jia, Shasha</creator><creator>Dong, Wanli</creator><creator>Zhou, Xianju</creator><creator>Chen, Zhiguo</creator><creator>Yun, Wenwei</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population</title><author>Jia, Shasha ; Dong, Wanli ; Zhou, Xianju ; Chen, Zhiguo ; Yun, Wenwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-7bb11acf0d83b00884ede2a6f24826053908d2aa042647d4b4c6f37f6928528d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>China</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Migraine Disorders - epidemiology</topic><topic>Migraine Disorders - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>TNF-Related Apoptosis-Inducing Ligand - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Shasha</creatorcontrib><creatorcontrib>Dong, Wanli</creatorcontrib><creatorcontrib>Zhou, Xianju</creatorcontrib><creatorcontrib>Chen, Zhiguo</creatorcontrib><creatorcontrib>Yun, Wenwei</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Shasha</au><au>Dong, Wanli</au><au>Zhou, Xianju</au><au>Chen, Zhiguo</au><au>Yun, Wenwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>43</volume><issue>3</issue><spage>326</spage><epage>331</epage><pages>326-331</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>Objective
To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
Methods
Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
Results
Rs35975099 was in Harvey–Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
Conclusion
There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25712717</pmid><doi>10.1177/0300060514565681</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0300-0605 |
| ispartof | Journal of international medical research, 2015-06, Vol.43 (3), p.326-331 |
| issn | 0300-0605 1473-2300 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adolescent Adult Aged Asian Continental Ancestry Group - genetics China Ethnic Groups - genetics Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genotype Humans Male Middle Aged Migraine Disorders - epidemiology Migraine Disorders - genetics Polymorphism, Single Nucleotide - genetics TNF-Related Apoptosis-Inducing Ligand - genetics Young Adult |
| title | Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population |
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