Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans

Highlights • Overexperssion of CPH1 rendered S. cerevisiae more susceptible to fluconazole. • CPH1 deletion in C. albicans increased MDR1 expression in the presence of 4-NQO. • CPH1 deletion mutants were more resistant to fluconazole and voriconazole. • CPH1 deletion had no effect on amphotericin B...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2015-06, Vol.45 (6), p.617-621
Main Authors: Lo, Hsiu-Jung, Tseng, Kuo-Yun, Kao, Yeong-Yi, Tsao, Ming-Yang, Lo, Han-Lun, Yang, Yun-Liang
Format: Article
Language:English
Subjects:
Amphotericin B - pharmacology
Animals
Antifungal Agents - pharmacology
Candida albicans
Candida albicans - drug effects
Candida albicans - genetics
Candida albicans - pathogenicity
Drug resistance
Drug Resistance, Multiple, Fungal
Efflux pump
Fluconazole - pharmacology
Fungal Proteins - genetics
Fungal Proteins - metabolism
Gene Expression
Gene Expression Regulation, Fungal
Gene Knockout Techniques
Infectious Disease
Mice
Regulation
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
Virulence
Virulence factor
Voriconazole - pharmacology
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Summary:Highlights • Overexperssion of CPH1 rendered S. cerevisiae more susceptible to fluconazole. • CPH1 deletion in C. albicans increased MDR1 expression in the presence of 4-NQO. • CPH1 deletion mutants were more resistant to fluconazole and voriconazole. • CPH1 deletion had no effect on amphotericin B susceptibility. • Hence, CPH1 negatively regulates MDR1 expression in resistance to azole compounds.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.01.017